Golfomycin A, a Novel Designed Molecule with DNA‐Cleaving Properties and Antitumor Activity

K. C. Nicolaou, Golfo Skokotas, S. Furuya, H. Suemune, D. Colette Nicolaou

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Retroaldol reaction, propargyl–allenyl isomerization, and [4 + 2] cycloaddition are the steps involved in the reaction of the title compound 1 with 1,8‐diazabi‐cyclo[5.4.0]undec‐7‐ene at room temperature in THF. The product 2, like 1, reacts readily with nucleophiles such as methyl thioglycolate. The biological activity of these compounds is presumably due to this reactivity. (Figure Presented.)

Original languageEnglish
Pages (from-to)1064-1067
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume29
Issue number9
DOIs
Publication statusPublished - Sep 1990
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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