Glycocalyx degradation in retinal and choroidal capillary endothelium in rats with diabetes and hypertension

Fumiaki Kumase, Yuki Morizane, Satoshi Mohri, Ippei Takasu, Aiji Ohtsuka, Hiroshi Ohtsukri

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15 Citations (Scopus)

Abstract

Endothelial glycocalyx (GCX) has been reported as a protective factor for vascular endothelial cells (VEC) in diabetes and hypertension. However, the involvement of GCX impairment in ocular vasculopathy remains unclear. We evaluated the changes in the GCX thicknesses of the retinal and choroidal capillaries in rats with diabetes and hypertension by cationic colloidal iron staining using a transmission electron microscope. In the control group, the mean (standard error of the mean) thicknesses of retinal and choroidal GCX were 60.2 (1.5) nm and 84.3 (3.1) nm, respectively. The diabetic rats showed a significant decrease of GCX thickness in the retina, but not in the choroid, compared to controls (28.3 (0.3) nm, p

Original languageEnglish
Pages (from-to)277-283
Number of pages7
JournalActa Medica Okayama
Volume64
Issue number5
Publication statusPublished - 2010

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Keywords

  • Choroid
  • Diabetes
  • Glycocalyx
  • Hypertension
  • Retina

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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