Glutamatergic Chemical Transmission: Look! Here, There, and Anywhere

Yoshinori Moriyama, Akitsugu Yamamoto

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalJournal of Biochemistry
Volume135
Issue number2
DOIs
Publication statusPublished - Feb 2004

Fingerprint

Vesicular Glutamate Transport Proteins
Organelles
Glutamic Acid
Pineal Gland
Endocrine Cells
Synaptic Vesicles
Active Biological Transport
Secretory Vesicles
Neurology
Modulators
Protein Isoforms
Central Nervous System
Cells
Hormones
Phenotype

Keywords

  • Acrosome
  • BNPI
  • Chemical transmission
  • DNPI
  • L-glutamate
  • Osteoblast
  • Secretory granule
  • Synaptic vesicle
  • Synaptic-like microvesicle
  • Vesicular glutamate transporter
  • VGLUT

ASJC Scopus subject areas

  • Biochemistry

Cite this

Glutamatergic Chemical Transmission : Look! Here, There, and Anywhere. / Moriyama, Yoshinori; Yamamoto, Akitsugu.

In: Journal of Biochemistry, Vol. 135, No. 2, 02.2004, p. 155-163.

Research output: Contribution to journalArticle

Moriyama, Yoshinori ; Yamamoto, Akitsugu. / Glutamatergic Chemical Transmission : Look! Here, There, and Anywhere. In: Journal of Biochemistry. 2004 ; Vol. 135, No. 2. pp. 155-163.
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