Glutamatergic Chemical Transmission: Look! Here, There, and Anywhere

Yoshinori Moriyama, Akitsugu Yamamoto

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)


Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalJournal of biochemistry
Issue number2
Publication statusPublished - Feb 2004


  • Acrosome
  • BNPI
  • Chemical transmission
  • DNPI
  • L-glutamate
  • Osteoblast
  • Secretory granule
  • Synaptic vesicle
  • Synaptic-like microvesicle
  • Vesicular glutamate transporter

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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