Abstract
Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.
| Original language | English |
|---|---|
| Pages (from-to) | 155-163 |
| Number of pages | 9 |
| Journal | Journal of Biochemistry |
| Volume | 135 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2004 |
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Keywords
- Acrosome
- BNPI
- Chemical transmission
- DNPI
- L-glutamate
- Osteoblast
- Secretory granule
- Synaptic vesicle
- Synaptic-like microvesicle
- Vesicular glutamate transporter
- VGLUT
ASJC Scopus subject areas
- Biochemistry
Cite this
Glutamatergic Chemical Transmission : Look! Here, There, and Anywhere. / Moriyama, Yoshinori; Yamamoto, Akitsugu.
In: Journal of Biochemistry, Vol. 135, No. 2, 02.2004, p. 155-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutamatergic Chemical Transmission
T2 - Look! Here, There, and Anywhere
AU - Moriyama, Yoshinori
AU - Yamamoto, Akitsugu
PY - 2004/2
Y1 - 2004/2
N2 - Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.
AB - Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.
KW - Acrosome
KW - BNPI
KW - Chemical transmission
KW - DNPI
KW - L-glutamate
KW - Osteoblast
KW - Secretory granule
KW - Synaptic vesicle
KW - Synaptic-like microvesicle
KW - Vesicular glutamate transporter
KW - VGLUT
UR - http://www.scopus.com/inward/record.url?scp=1842734876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842734876&partnerID=8YFLogxK
U2 - 10.1093/jb/mvh018
DO - 10.1093/jb/mvh018
M3 - Article
C2 - 15047716
AN - SCOPUS:1842734876
VL - 135
SP - 155
EP - 163
JO - Journal of Biochemistry
JF - Journal of Biochemistry
SN - 0021-924X
IS - 2
ER -