Glucose, some amino acids and a plant secondary metabolite, chlorogenic acid induce the secretion of a regulatory hormone, tachykinin-related peptide, from the silkworm midgut

Takayuki Yamagishi, Haruka Endo, Keisuke Fukumura, Shinji Nagata, Tohru Hayakawa, Satomi Adegawa, Mayu Kasubuchi, Ryoichi Sato

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Enteroendocrine cells in the insect midgut are thought to secrete peptide hormones in response to the nutritional state. However, the role of dietary compounds in inducing peptide hormone secretion from enteroendocrine cells in insects remains unknown. In the present study, we demonstrated that several dietary compounds from mulberry leaves, including glucose, amino acids, and the secondary metabolite chlorogenic acid, induced significant secretion of tachykinin-related peptides from isolated silkworm midguts at the luminal concentrations measured in fed larvae. This study provides evidence that the insect midgut senses a non-nutritious secondary metabolite in addition to nutrient metabolites to monitor luminal food status and secretes a feeding regulatory hormone, suggesting that a unique dietary sensory system modulates insect feeding via enteroendocrine control.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalPeptides
Volume106
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Chlorogenic Acid
Tachykinins
Bombyx
Metabolites
Insects
Peptide Hormones
Enteroendocrine Cells
Hormones
Amino Acids
Glucose
Peptides
Imino Acids
Morus
Food
Nutrients
Larva

Keywords

  • Bombyx mori
  • Enteroendocrine cell
  • Nutrient
  • Secondary metabolite
  • Secretion
  • Tachykinin-related peptide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Glucose, some amino acids and a plant secondary metabolite, chlorogenic acid induce the secretion of a regulatory hormone, tachykinin-related peptide, from the silkworm midgut. / Yamagishi, Takayuki; Endo, Haruka; Fukumura, Keisuke; Nagata, Shinji; Hayakawa, Tohru; Adegawa, Satomi; Kasubuchi, Mayu; Sato, Ryoichi.

In: Peptides, Vol. 106, 01.08.2018, p. 21-27.

Research output: Contribution to journalArticle

Yamagishi, Takayuki ; Endo, Haruka ; Fukumura, Keisuke ; Nagata, Shinji ; Hayakawa, Tohru ; Adegawa, Satomi ; Kasubuchi, Mayu ; Sato, Ryoichi. / Glucose, some amino acids and a plant secondary metabolite, chlorogenic acid induce the secretion of a regulatory hormone, tachykinin-related peptide, from the silkworm midgut. In: Peptides. 2018 ; Vol. 106. pp. 21-27.
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AU - Nagata, Shinji

AU - Hayakawa, Tohru

AU - Adegawa, Satomi

AU - Kasubuchi, Mayu

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