Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report

Hiroki Fujii, Satoshi Kubo, Taijun Yunoki, Kouta Sato, Kazuhiro Takamatsu, Keiko Tanaka, Yukitoshi Takahashi, Masaru Kuriyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 54-year-old woman presented with complex partial seizure with impaired consciousness. Brain MRI revealed a high intensity lesion on T 2-weighted and FLAIR images in the left temporal lobe, indicating limbic encephalitis. CT and MRI of the pelvis showed right ovarian teratoma. The cerebrospinal fluid (CSF) were positive for antibodies against the GluRε 2, GluRδ 2, and antibodies against NR1 + NR2B heteromers. On the basis of these data, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis associated with ovarian teratoma was suspected, and the right ovariectomy was performed. Six months after onset, brain biopsy from the right temporal lobe led to a diagnosed of glioblastoma. This is the first glioblastoma case with ovarian teratoma having autoantibodies against GluR and NR1 + NR2B heteromers in CSF. We suggest that patients with NMDAR antibodies should be carefully diagnosed with anti-NMDAR encephalitis.

Original languageEnglish
Pages (from-to)712-715
Number of pages4
JournalClinical Neurology
Volume53
Issue number9
DOIs
Publication statusPublished - Sep 1 2013

Keywords

  • Anti-N-methyl-D-aspartate receptor antibody
  • Glioblastoma
  • Limbic encephalitis
  • Ovarian teratoma

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Fujii, H., Kubo, S., Yunoki, T., Sato, K., Takamatsu, K., Tanaka, K., Takahashi, Y., & Kuriyama, M. (2013). Glioblastoma with ovarian teratoma having N-methyl-D-aspartate receptor (NMDAR) antibody in CSF-A case report. Clinical Neurology, 53(9), 712-715. https://doi.org/10.5692/clinicalneurol.53.712