Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

Keisuke Oshimi; Yushi Nishimura; Tsutomu Matsubara; Masuaki Tanaka; Eiji Shikoh; Li Zhao; Yajuan Zou; Naoki Komatsu; Yuta Ikado; Yuka Takezawa; Eriko Kage-Nakadai; Yumi Izutsu; Katsutoshi Yoshizato; Saho Morita; Masato Tokunaga; Hiroshi Yukawa; Yoshinobu Baba; Yoshio Teki; Masazumi Fujiwara

doi:10.1039/d2lc00112h

Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

Keisuke Oshimi, Yushi Nishimura, Tsutomu Matsubara, Masuaki Tanaka, Eiji Shikoh, Li Zhao, Yajuan Zou, Naoki Komatsu, Yuta Ikado, Yuka Takezawa, Eriko Kage-Nakadai, Yumi Izutsu, Katsutoshi Yoshizato, Saho Morita, Masato Tokunaga, Hiroshi Yukawa, Yoshinobu Baba, Yoshio Teki, Masazumi Fujiwara

Research output: Contribution to journal › Article › peer-review

Abstract

We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

Original language	English
Pages (from-to)	2519-2530
Number of pages	12
Journal	Lab on a Chip
Volume	22
Issue number	13
DOIs	https://doi.org/10.1039/d2lc00112h
Publication status	Published - Jun 28 2022

ASJC Scopus subject areas

Bioengineering
Biochemistry
Chemistry(all)
Biomedical Engineering

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10.1039/d2lc00112h

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Oshimi, K., Nishimura, Y., Matsubara, T., Tanaka, M., Shikoh, E., Zhao, L., Zou, Y., Komatsu, N., Ikado, Y., Takezawa, Y., Kage-Nakadai, E., Izutsu, Y., Yoshizato, K., Morita, S., Tokunaga, M., Yukawa, H., Baba, Y., Teki, Y., & Fujiwara, M. (2022). Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples. Lab on a Chip, 22(13), 2519-2530. https://doi.org/10.1039/d2lc00112h

Oshimi, K, Nishimura, Y, Matsubara, T, Tanaka, M, Shikoh, E, Zhao, L, Zou, Y, Komatsu, N, Ikado, Y, Takezawa, Y, Kage-Nakadai, E, Izutsu, Y, Yoshizato, K, Morita, S, Tokunaga, M, Yukawa, H, Baba, Y, Teki, Y & Fujiwara, M 2022, 'Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples', Lab on a Chip, vol. 22, no. 13, pp. 2519-2530. https://doi.org/10.1039/d2lc00112h

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title = "Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples",

abstract = "We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.",

author = "Keisuke Oshimi and Yushi Nishimura and Tsutomu Matsubara and Masuaki Tanaka and Eiji Shikoh and Li Zhao and Yajuan Zou and Naoki Komatsu and Yuta Ikado and Yuka Takezawa and Eriko Kage-Nakadai and Yumi Izutsu and Katsutoshi Yoshizato and Saho Morita and Masato Tokunaga and Hiroshi Yukawa and Yoshinobu Baba and Yoshio Teki and Masazumi Fujiwara",

year = "2022",

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doi = "10.1039/d2lc00112h",

language = "English",

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AU - Oshimi, Keisuke

AU - Nishimura, Yushi

AU - Matsubara, Tsutomu

AU - Tanaka, Masuaki

AU - Shikoh, Eiji

AU - Zhao, Li

AU - Zou, Yajuan

AU - Komatsu, Naoki

AU - Ikado, Yuta

AU - Takezawa, Yuka

AU - Kage-Nakadai, Eriko

AU - Izutsu, Yumi

AU - Yoshizato, Katsutoshi

AU - Morita, Saho

AU - Tokunaga, Masato

AU - Yukawa, Hiroshi

AU - Baba, Yoshinobu

AU - Teki, Yoshio

AU - Fujiwara, Masazumi

PY - 2022/6/28

Y1 - 2022/6/28

N2 - We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

AB - We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm2) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

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Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

Abstract

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