GLASS MICROFLUIDIC PLATFORM FOR NANOWIRE-ASSISTED URINARY CELL-FREE DNA ISOLATION

Hiromi Takahashi, Takao Yasui, Keiko Shinjo, Yusuke Miyazaki, Wataru Shinoda, Takeshi Hasegawa, Yotaro Kitano, Yoshinobu Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Driven by the importance of urinary cell-free DNA (cfDNA) as cancer biomarkers, the effectiveness of cfDNA isolation from body fluids can impact clinical usability, especially for molecular diagnostic. However, cfDNA isolations are currently hampered by the dilution of small fragmented cfDNA in body fluids. In this work, we report the unique properties of nanowires assisting the isolation of urinary cfDNA based on specific chemical interactions, maximizing the effectiveness of the platform that could never be achieved with the conventional methods.

Original languageEnglish
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1401-1402
Number of pages2
ISBN (Electronic)9781733419031
Publication statusPublished - 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, United States
Duration: Oct 10 2021Oct 14 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUnited States
CityPalm Springs, Virtual
Period10/10/2110/14/21

Keywords

  • Cell-free DNA
  • Glass
  • Liquid-biopsy
  • Nanowires
  • Nucleic acid isolation

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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