Giant insulinoma in a patient with multiple endocrine neoplasia-type I: A case report

Hideo Kataoka, Fumio Otsuka, Takayoshi Yamauchi, Masayuki Kishida, Masami Takahashi, Takashi Tamiya, Yukari Mimura, Toshio Ogura, Hirofumi Makino

Research output: Contribution to journalArticle

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Abstract

We report a case of giant cystic insulinoma constituting part of multiple endocrine neoplasia (MEN) type I. A 29-year-old Japanese man presented with a history of recurrent hypoglycemic attacks. Endocrine examination showed hyperinsulinemia discordant with hypoglycemia, and a giant cystic insulinoma (11 x 10 cm) located in the pancreatic tail was detected radiologically. Hyperprolactinemia due to pituitary adenoma and hyperparathyroidism due to parathyroid hyperplasia were also present. The insulinoma, prolactinoma and hyperplastic parathyroid gland were surgically removed. Fluorescent microsatellite analysis detected loss of heterozygosity (LOH) in chromosome 11q13 in DNA samples from all resected tissues but not from white blood cells. This is a rare case of MEN type I because of the giant cystic insulinoma and the evidence of common LOH detected in all MEN type I tissues.

Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalEndocrine Journal
Volume46
Issue number3
Publication statusPublished - Jun 1999

Fingerprint

Multiple Endocrine Neoplasia Type 1
Insulinoma
Loss of Heterozygosity
N,N-dimethyl-3,3-diphenyl-1-methylallylamine
Prolactinoma
Hyperprolactinemia
Parathyroid Glands
Hyperparathyroidism
Hyperinsulinism
Pituitary Neoplasms
Hypoglycemia
Hypoglycemic Agents
Microsatellite Repeats
Hyperplasia
Leukocytes
Chromosomes
DNA

Keywords

  • Chromosome 11q13
  • Hyperparathyroidism
  • Insulinoma
  • Loss of heterozygosity (LOH)
  • Multiple endocrine neoplasia (MEN) type I
  • Prolactinoma

ASJC Scopus subject areas

  • Endocrinology

Cite this

Kataoka, H., Otsuka, F., Yamauchi, T., Kishida, M., Takahashi, M., Tamiya, T., ... Makino, H. (1999). Giant insulinoma in a patient with multiple endocrine neoplasia-type I: A case report. Endocrine Journal, 46(3), 429-435.

Giant insulinoma in a patient with multiple endocrine neoplasia-type I : A case report. / Kataoka, Hideo; Otsuka, Fumio; Yamauchi, Takayoshi; Kishida, Masayuki; Takahashi, Masami; Tamiya, Takashi; Mimura, Yukari; Ogura, Toshio; Makino, Hirofumi.

In: Endocrine Journal, Vol. 46, No. 3, 06.1999, p. 429-435.

Research output: Contribution to journalArticle

Kataoka, H, Otsuka, F, Yamauchi, T, Kishida, M, Takahashi, M, Tamiya, T, Mimura, Y, Ogura, T & Makino, H 1999, 'Giant insulinoma in a patient with multiple endocrine neoplasia-type I: A case report', Endocrine Journal, vol. 46, no. 3, pp. 429-435.
Kataoka H, Otsuka F, Yamauchi T, Kishida M, Takahashi M, Tamiya T et al. Giant insulinoma in a patient with multiple endocrine neoplasia-type I: A case report. Endocrine Journal. 1999 Jun;46(3):429-435.
Kataoka, Hideo ; Otsuka, Fumio ; Yamauchi, Takayoshi ; Kishida, Masayuki ; Takahashi, Masami ; Tamiya, Takashi ; Mimura, Yukari ; Ogura, Toshio ; Makino, Hirofumi. / Giant insulinoma in a patient with multiple endocrine neoplasia-type I : A case report. In: Endocrine Journal. 1999 ; Vol. 46, No. 3. pp. 429-435.
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