Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factor for localized nodal DLBCL.

Toshiyuki Habara, Yasuharu Sato, Katsuyoshi Takata, Noriko Iwaki, Hirokazu Okumura, Hiroshi Sonobe, Takehiro Tanaka, Yorihisa Orita, L. A. Al-Kader, Naoko Asano, Daisuke Ennishi, Tadashi Yoshino

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Although many investigations have been performed on the prognostic factors of DLBCL, no reports have focused on localized nodal DLBCL. We examined the prognostic significance of 39 Japanese patients with localized nodal DLBCL with special reference to the germinal center B-cell-like (GCB) versus non-germinal center B-cell-like (NGCB) types. The median age was 65 years with 23 males and 16 females. Using Hans algorithm of immunohistochemistry, 18 patients (46%) exhibited GCB type and 21 (54%) exhibited NGCB type. Twenty-nine patients (74%) presented with disease in the neck (neck group) and 10 (26%) had disease in non-neck regions (non-neck group). Comparing Hans, Choi, and Muris algorithms, patients with GCB type showed statistically significant progression-free survival (PFS) only with Hans algorithm (P = 0.022, P = 0.100, and P = 0.130, respectively). Patient survival analyses revealed that GCB-type patients by Hans algorithm had a better PFS (P = 0.012), and neck-group patients had better PFS and overall survival (OS) (P = 0.018 and P = 0.012, respectively). Univariate analysis revealed that only neck vs. non-neck exhibited a significant difference in terms of OS (P = 0.026). Multivariate analysis revealed that GCB type by Hans algorithm and neck vs. non-neck were significantly different in terms of PFS (P = 0.025 and P = 0.033, respectively). Therefore, the subclassifications of GCB type vs. NGCB type and neck vs. non-neck are important predictive prognostic factors in localized nodal DLBCL.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalJournal of clinical and experimental hematopathology : JCEH
Volume52
Issue number2
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Germinal Center
Lymphoma, Large B-Cell, Diffuse
B-Lymphocytes
Neck
Disease-Free Survival
Survival
Survival Analysis
Non-Hodgkin's Lymphoma
Multivariate Analysis
Immunohistochemistry

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factor for localized nodal DLBCL. / Habara, Toshiyuki; Sato, Yasuharu; Takata, Katsuyoshi; Iwaki, Noriko; Okumura, Hirokazu; Sonobe, Hiroshi; Tanaka, Takehiro; Orita, Yorihisa; Al-Kader, L. A.; Asano, Naoko; Ennishi, Daisuke; Yoshino, Tadashi.

In: Journal of clinical and experimental hematopathology : JCEH, Vol. 52, No. 2, 2012, p. 91-99.

Research output: Contribution to journalArticle

Habara, Toshiyuki ; Sato, Yasuharu ; Takata, Katsuyoshi ; Iwaki, Noriko ; Okumura, Hirokazu ; Sonobe, Hiroshi ; Tanaka, Takehiro ; Orita, Yorihisa ; Al-Kader, L. A. ; Asano, Naoko ; Ennishi, Daisuke ; Yoshino, Tadashi. / Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factor for localized nodal DLBCL. In: Journal of clinical and experimental hematopathology : JCEH. 2012 ; Vol. 52, No. 2. pp. 91-99.
@article{999ae0c1544d4c42a0b803a61205960a,
title = "Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factor for localized nodal DLBCL.",
abstract = "Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Although many investigations have been performed on the prognostic factors of DLBCL, no reports have focused on localized nodal DLBCL. We examined the prognostic significance of 39 Japanese patients with localized nodal DLBCL with special reference to the germinal center B-cell-like (GCB) versus non-germinal center B-cell-like (NGCB) types. The median age was 65 years with 23 males and 16 females. Using Hans algorithm of immunohistochemistry, 18 patients (46{\%}) exhibited GCB type and 21 (54{\%}) exhibited NGCB type. Twenty-nine patients (74{\%}) presented with disease in the neck (neck group) and 10 (26{\%}) had disease in non-neck regions (non-neck group). Comparing Hans, Choi, and Muris algorithms, patients with GCB type showed statistically significant progression-free survival (PFS) only with Hans algorithm (P = 0.022, P = 0.100, and P = 0.130, respectively). Patient survival analyses revealed that GCB-type patients by Hans algorithm had a better PFS (P = 0.012), and neck-group patients had better PFS and overall survival (OS) (P = 0.018 and P = 0.012, respectively). Univariate analysis revealed that only neck vs. non-neck exhibited a significant difference in terms of OS (P = 0.026). Multivariate analysis revealed that GCB type by Hans algorithm and neck vs. non-neck were significantly different in terms of PFS (P = 0.025 and P = 0.033, respectively). Therefore, the subclassifications of GCB type vs. NGCB type and neck vs. non-neck are important predictive prognostic factors in localized nodal DLBCL.",
author = "Toshiyuki Habara and Yasuharu Sato and Katsuyoshi Takata and Noriko Iwaki and Hirokazu Okumura and Hiroshi Sonobe and Takehiro Tanaka and Yorihisa Orita and Al-Kader, {L. A.} and Naoko Asano and Daisuke Ennishi and Tadashi Yoshino",
year = "2012",
language = "English",
volume = "52",
pages = "91--99",
journal = "Journal of clinical and experimental hematopathology : JCEH",
issn = "1346-4280",
publisher = "Nihon Rinpa Monaikei Gakkai",
number = "2",

}

TY - JOUR

T1 - Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factor for localized nodal DLBCL.

AU - Habara, Toshiyuki

AU - Sato, Yasuharu

AU - Takata, Katsuyoshi

AU - Iwaki, Noriko

AU - Okumura, Hirokazu

AU - Sonobe, Hiroshi

AU - Tanaka, Takehiro

AU - Orita, Yorihisa

AU - Al-Kader, L. A.

AU - Asano, Naoko

AU - Ennishi, Daisuke

AU - Yoshino, Tadashi

PY - 2012

Y1 - 2012

N2 - Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Although many investigations have been performed on the prognostic factors of DLBCL, no reports have focused on localized nodal DLBCL. We examined the prognostic significance of 39 Japanese patients with localized nodal DLBCL with special reference to the germinal center B-cell-like (GCB) versus non-germinal center B-cell-like (NGCB) types. The median age was 65 years with 23 males and 16 females. Using Hans algorithm of immunohistochemistry, 18 patients (46%) exhibited GCB type and 21 (54%) exhibited NGCB type. Twenty-nine patients (74%) presented with disease in the neck (neck group) and 10 (26%) had disease in non-neck regions (non-neck group). Comparing Hans, Choi, and Muris algorithms, patients with GCB type showed statistically significant progression-free survival (PFS) only with Hans algorithm (P = 0.022, P = 0.100, and P = 0.130, respectively). Patient survival analyses revealed that GCB-type patients by Hans algorithm had a better PFS (P = 0.012), and neck-group patients had better PFS and overall survival (OS) (P = 0.018 and P = 0.012, respectively). Univariate analysis revealed that only neck vs. non-neck exhibited a significant difference in terms of OS (P = 0.026). Multivariate analysis revealed that GCB type by Hans algorithm and neck vs. non-neck were significantly different in terms of PFS (P = 0.025 and P = 0.033, respectively). Therefore, the subclassifications of GCB type vs. NGCB type and neck vs. non-neck are important predictive prognostic factors in localized nodal DLBCL.

AB - Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. Although many investigations have been performed on the prognostic factors of DLBCL, no reports have focused on localized nodal DLBCL. We examined the prognostic significance of 39 Japanese patients with localized nodal DLBCL with special reference to the germinal center B-cell-like (GCB) versus non-germinal center B-cell-like (NGCB) types. The median age was 65 years with 23 males and 16 females. Using Hans algorithm of immunohistochemistry, 18 patients (46%) exhibited GCB type and 21 (54%) exhibited NGCB type. Twenty-nine patients (74%) presented with disease in the neck (neck group) and 10 (26%) had disease in non-neck regions (non-neck group). Comparing Hans, Choi, and Muris algorithms, patients with GCB type showed statistically significant progression-free survival (PFS) only with Hans algorithm (P = 0.022, P = 0.100, and P = 0.130, respectively). Patient survival analyses revealed that GCB-type patients by Hans algorithm had a better PFS (P = 0.012), and neck-group patients had better PFS and overall survival (OS) (P = 0.018 and P = 0.012, respectively). Univariate analysis revealed that only neck vs. non-neck exhibited a significant difference in terms of OS (P = 0.026). Multivariate analysis revealed that GCB type by Hans algorithm and neck vs. non-neck were significantly different in terms of PFS (P = 0.025 and P = 0.033, respectively). Therefore, the subclassifications of GCB type vs. NGCB type and neck vs. non-neck are important predictive prognostic factors in localized nodal DLBCL.

UR - http://www.scopus.com/inward/record.url?scp=84874577274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874577274&partnerID=8YFLogxK

M3 - Article

C2 - 23037624

AN - SCOPUS:84874577274

VL - 52

SP - 91

EP - 99

JO - Journal of clinical and experimental hematopathology : JCEH

JF - Journal of clinical and experimental hematopathology : JCEH

SN - 1346-4280

IS - 2

ER -