Geranyl derivatives of isoquinoline alkaloids show increased biological activities

Yumi Nishiyama; Kinuko Iwasa; Suguru Okada; Sousuke Takeuchi; Masataka Moriyasu; Miyoko Kamigauchi; Junko Koyama; Atsuko Takeuchi; Harukuni Tokuda; Hye Sook Kim; Yusuke Wataya; Kazuyoshi Takeda; Yi Nan Liu; Pei Chi Wu; Kenneth F. Bastow; Toshiyuki Akiyama; Kuo Hsiung Lee

doi:10.3987/COM-10-11912

Geranyl derivatives of isoquinoline alkaloids show increased biological activities

Yumi Nishiyama, Kinuko Iwasa, Suguru Okada, Sousuke Takeuchi, Masataka Moriyasu, Miyoko Kamigauchi, Junko Koyama, Atsuko Takeuchi, Harukuni Tokuda, Hye Sook Kim, Yusuke Wataya, Kazuyoshi Takeda, Yi Nan Liu, Pei Chi Wu, Kenneth F. Bastow, Toshiyuki Akiyama, Kuo Hsiung Lee

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.

Original language	English
Pages (from-to)	1193-1229
Number of pages	37
Journal	Heterocycles
Volume	81
Issue number	5
DOIs	https://doi.org/10.3987/COM-10-11912
Publication status	Published - 2010

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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Nishiyama, Y., Iwasa, K., Okada, S., Takeuchi, S., Moriyasu, M., Kamigauchi, M., Koyama, J., Takeuchi, A., Tokuda, H., Kim, H. S., Wataya, Y., Takeda, K., Liu, Y. N., Wu, P. C., Bastow, K. F., Akiyama, T., & Lee, K. H. (2010). Geranyl derivatives of isoquinoline alkaloids show increased biological activities. Heterocycles, 81(5), 1193-1229. https://doi.org/10.3987/COM-10-11912

Geranyl derivatives of isoquinoline alkaloids show increased biological activities. / Nishiyama, Yumi; Iwasa, Kinuko; Okada, Suguru; Takeuchi, Sousuke; Moriyasu, Masataka; Kamigauchi, Miyoko; Koyama, Junko; Takeuchi, Atsuko; Tokuda, Harukuni; Kim, Hye Sook; Wataya, Yusuke; Takeda, Kazuyoshi; Liu, Yi Nan; Wu, Pei Chi; Bastow, Kenneth F.; Akiyama, Toshiyuki; Lee, Kuo Hsiung.

In: Heterocycles, Vol. 81, No. 5, 2010, p. 1193-1229.

Research output: Contribution to journal › Article › peer-review

Nishiyama, Yumi ; Iwasa, Kinuko ; Okada, Suguru ; Takeuchi, Sousuke ; Moriyasu, Masataka ; Kamigauchi, Miyoko ; Koyama, Junko ; Takeuchi, Atsuko ; Tokuda, Harukuni ; Kim, Hye Sook ; Wataya, Yusuke ; Takeda, Kazuyoshi ; Liu, Yi Nan ; Wu, Pei Chi ; Bastow, Kenneth F. ; Akiyama, Toshiyuki ; Lee, Kuo Hsiung. / Geranyl derivatives of isoquinoline alkaloids show increased biological activities. In: Heterocycles. 2010 ; Vol. 81, No. 5. pp. 1193-1229.

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AU - Wataya, Yusuke

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AU - Akiyama, Toshiyuki

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