Abstract
Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.
Original language | English |
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Pages (from-to) | 1193-1229 |
Number of pages | 37 |
Journal | Heterocycles |
Volume | 81 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2010 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry