Geranyl derivatives of isoquinoline alkaloids show increased biological activities

Yumi Nishiyama; Kinuko Iwasa; Suguru Okada; Sousuke Takeuchi; Masataka Moriyasu; Miyoko Kamigauchi; Junko Koyama; Atsuko Takeuchi; Harukuni Tokuda; Hye Sook Kim; Yusuke Wataya; Kazuyoshi Takeda; Yi Nan Liu; Pei Chi Wu; Kenneth F. Bastow; Toshiyuki Akiyama; Kuo Hsiung Lee

doi:10.3987/COM-10-11912

Geranyl derivatives of isoquinoline alkaloids show increased biological activities

Yumi Nishiyama, Kinuko Iwasa, Suguru Okada, Sousuke Takeuchi, Masataka Moriyasu, Miyoko Kamigauchi, Junko Koyama, Atsuko Takeuchi, Harukuni Tokuda, Hye Sook Kim, Yusuke Wataya, Kazuyoshi Takeda, Yi Nan Liu, Pei Chi Wu, Kenneth F. Bastow, Toshiyuki Akiyama, Kuo Hsiung Lee

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.

Original language	English
Pages (from-to)	1193-1229
Number of pages	37
Journal	Heterocycles
Volume	81
Issue number	5
DOIs	https://doi.org/10.3987/COM-10-11912
Publication status	Published - 2010

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3987/COM-10-11912

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Nishiyama, Y., Iwasa, K., Okada, S., Takeuchi, S., Moriyasu, M., Kamigauchi, M., Koyama, J., Takeuchi, A., Tokuda, H., Kim, H. S., Wataya, Y., Takeda, K., Liu, Y. N., Wu, P. C., Bastow, K. F., Akiyama, T., & Lee, K. H. (2010). Geranyl derivatives of isoquinoline alkaloids show increased biological activities. Heterocycles, 81(5), 1193-1229. https://doi.org/10.3987/COM-10-11912

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title = "Geranyl derivatives of isoquinoline alkaloids show increased biological activities",

abstract = "Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.",

author = "Yumi Nishiyama and Kinuko Iwasa and Suguru Okada and Sousuke Takeuchi and Masataka Moriyasu and Miyoko Kamigauchi and Junko Koyama and Atsuko Takeuchi and Harukuni Tokuda and Kim, {Hye Sook} and Yusuke Wataya and Kazuyoshi Takeda and Liu, {Yi Nan} and Wu, {Pei Chi} and Bastow, {Kenneth F.} and Toshiyuki Akiyama and Lee, {Kuo Hsiung}",

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doi = "10.3987/COM-10-11912",

language = "English",

volume = "81",

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T1 - Geranyl derivatives of isoquinoline alkaloids show increased biological activities

AU - Nishiyama, Yumi

AU - Iwasa, Kinuko

AU - Okada, Suguru

AU - Takeuchi, Sousuke

AU - Moriyasu, Masataka

AU - Kamigauchi, Miyoko

AU - Koyama, Junko

AU - Takeuchi, Atsuko

AU - Tokuda, Harukuni

AU - Kim, Hye Sook

AU - Wataya, Yusuke

AU - Takeda, Kazuyoshi

AU - Liu, Yi Nan

AU - Wu, Pei Chi

AU - Bastow, Kenneth F.

AU - Akiyama, Toshiyuki

AU - Lee, Kuo Hsiung

PY - 2010

Y1 - 2010

N2 - Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.

AB - Three types of isoquinoline alkaloids were tested for antimicrobial, cytotoxic, anti-malarial, anti-oxidant, and anti-HIV activities, as well as inhibitory activity against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. N-or O-Geranylation contributed to increased potency in four types of activities except anti-HIV and anti-oxidant. Some types of alkaloids may be useful as lead compounds for developing potential chemotherapeutic agents. N,N-Geranylated salsolinol was significantly active in three different assays, antimicrobial, cytotoxic, and EBV-EA, and may be a most useful compound.

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JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 5

ER -

Geranyl derivatives of isoquinoline alkaloids show increased biological activities

Abstract

ASJC Scopus subject areas

UN SDGs

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