Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas

Mehmet Gunduz, Mamoru Ouchida, Kunihiro Fukushima, Hiroko Hanafusa, Tsutomu Etani, Shinji Nishioka, Kazunori Nishizaki, Kenji Shimizu

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)

Abstract

We characterized the genomic structure of the human ING1 gene, a candidate tumor suppressor gene, and found that the gene has three exons. We also demonstrated that four mRNA variants were transcribed from three different promoter regions. Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. Here we present the first report that three missense mutations and three silent changes were detected in the ING1 gene in 6 of 23 tumors with allelic loss at the 13q33-34 region. These missense mutations were found within the PHD finger domain and nuclear localization motif in ING1 protein, probably abrogating the normal function.

Original languageEnglish
Pages (from-to)3143-3146
Number of pages4
JournalCancer Research
Volume60
Issue number12
Publication statusPublished - Jun 15 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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