Genomic reorganization by IS26 in a blaNDM-5-bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan

Dan Takeuchi, Yukihiro Akeda, Hisao Yoshida, Hideharu Hagiya, Norihisa Yamamoto, Isao Nishi, Nori Yoshioka, Yo Sugawara, Noriko Sakamoto, Rathina Kumar Shanmugakani, Matsuo Deguchi, Kazunori Tomono, Shigeyuki Hamada

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3 Citations (Scopus)

Abstract

An NDM-5-producing Klebsiella pneumoniae ST147 strain was isolated from a Japanese patient who had not travelled abroad in at least 5 years. Whole-genome sequencing revealed a genomic rearrangement in an FII plasmid harbouring blaNDM-5 due to the replicative transposition of IS26. A hypothetical structure was proposed for its ancestral plasmid, and comparative genomic analysis of the plasmid suggested the dissemination of structurally similar plasmids harbouring blaNDM-5 in Asian and Middle Eastern countries.

Original languageEnglish
Article number000817
Pages (from-to)1221-1224
Number of pages4
JournalJournal of Medical Microbiology
Volume67
Issue number9
DOIs
Publication statusPublished - Sep 2018

Keywords

  • Bla
  • Genomic reorganization
  • IS26
  • IncFII plasmid

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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    Takeuchi, D., Akeda, Y., Yoshida, H., Hagiya, H., Yamamoto, N., Nishi, I., Yoshioka, N., Sugawara, Y., Sakamoto, N., Shanmugakani, R. K., Deguchi, M., Tomono, K., & Hamada, S. (2018). Genomic reorganization by IS26 in a blaNDM-5-bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan. Journal of Medical Microbiology, 67(9), 1221-1224. [000817]. https://doi.org/10.1099/jmm.0.000817