Genomic reorganization by IS26 in a blaNDM-5-bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan

Dan Takeuchi, Yukihiro Akeda, Hisao Yoshida, Hideharu Hagiya, Norihisa Yamamoto, Isao Nishi, Nori Yoshioka, Yo Sugawara, Noriko Sakamoto, Rathina Kumar Shanmugakani, Matsuo Deguchi, Kazunori Tomono, Shigeyuki Hamada

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


An NDM-5-producing Klebsiella pneumoniae ST147 strain was isolated from a Japanese patient who had not travelled abroad in at least 5 years. Whole-genome sequencing revealed a genomic rearrangement in an FII plasmid harbouring blaNDM-5 due to the replicative transposition of IS26. A hypothetical structure was proposed for its ancestral plasmid, and comparative genomic analysis of the plasmid suggested the dissemination of structurally similar plasmids harbouring blaNDM-5 in Asian and Middle Eastern countries.

Original languageEnglish
Article number000817
Pages (from-to)1221-1224
Number of pages4
JournalJournal of Medical Microbiology
Issue number9
Publication statusPublished - Sep 2018


  • Bla
  • Genomic reorganization
  • IS26
  • IncFII plasmid

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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