Genomic reorganization by IS26 in a bla NDM-5 -bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan

Dan Takeuchi, Yukihiro Akeda, Hisao Yoshida, Hideharu Hagiya, Norihisa Yamamoto, Isao Nishi, Nori Yoshioka, Yo Sugawara, Noriko Sakamoto, Rathina Kumar Shanmugakani, Matsuo Deguchi, Kazunori Tomono, Shigeyuki Hamada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An NDM-5-producing Klebsiella pneumoniae ST147 strain was isolated from a Japanese patient who had not travelled abroad in at least 5 years. Whole-genome sequencing revealed a genomic rearrangement in an FII plasmid harbouring bla NDM-5 due to the replicative transposition of IS26. A hypothetical structure was proposed for its ancestral plasmid, and comparative genomic analysis of the plasmid suggested the dissemination of structurally similar plasmids harbouring bla NDM-5 in Asian and Middle Eastern countries.

Original languageEnglish
Article number000817
Pages (from-to)1221-1224
Number of pages4
JournalJournal of Medical Microbiology
Volume67
Issue number9
DOIs
Publication statusPublished - Sep 2018
Externally publishedYes

Fingerprint

Klebsiella pneumoniae
Japan
Plasmids
Genome

Keywords

  • Bla
  • Genomic reorganization
  • IncFII plasmid
  • IS26

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Genomic reorganization by IS26 in a bla NDM-5 -bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan . / Takeuchi, Dan; Akeda, Yukihiro; Yoshida, Hisao; Hagiya, Hideharu; Yamamoto, Norihisa; Nishi, Isao; Yoshioka, Nori; Sugawara, Yo; Sakamoto, Noriko; Shanmugakani, Rathina Kumar; Deguchi, Matsuo; Tomono, Kazunori; Hamada, Shigeyuki.

In: Journal of Medical Microbiology, Vol. 67, No. 9, 000817, 09.2018, p. 1221-1224.

Research output: Contribution to journalArticle

Takeuchi, D, Akeda, Y, Yoshida, H, Hagiya, H, Yamamoto, N, Nishi, I, Yoshioka, N, Sugawara, Y, Sakamoto, N, Shanmugakani, RK, Deguchi, M, Tomono, K & Hamada, S 2018, ' Genomic reorganization by IS26 in a bla NDM-5 -bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan ', Journal of Medical Microbiology, vol. 67, no. 9, 000817, pp. 1221-1224. https://doi.org/10.1099/jmm.0.000817
Takeuchi, Dan ; Akeda, Yukihiro ; Yoshida, Hisao ; Hagiya, Hideharu ; Yamamoto, Norihisa ; Nishi, Isao ; Yoshioka, Nori ; Sugawara, Yo ; Sakamoto, Noriko ; Shanmugakani, Rathina Kumar ; Deguchi, Matsuo ; Tomono, Kazunori ; Hamada, Shigeyuki. / Genomic reorganization by IS26 in a bla NDM-5 -bearing FII plasmid of klebsiella pneumoniae isolated from a patient in Japan In: Journal of Medical Microbiology. 2018 ; Vol. 67, No. 9. pp. 1221-1224.
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AU - Nishi, Isao

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