Genomic analysis of mefloquine-resistant Plasmodium falciparum.

Khurshida Begum, Hye-Sook Kim, Yohei Okuda, Yusuke Wataya, Mikio Kimura, Takahisa Huruta

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

We studied sequence polymorphism, expression level of pfmdr1 gene and drug sensitivity in mefloquine sensitive-strain as well as mefloquine-resistant clone/24 to understand underlying drug resistance mechanism. Mefloquine-resistant clone/24 exhibited decreased susceptibility to mefloquine, quinine, halofantrine and artemisinin and increased susceptibility to chloroquine. We analyzed sequence of pfmdr1 gene and found mutation in pfmdr1 on clone/24. Moreover, overexpression of mRNA level of pfmdr1 has been observed in mefloquine-resistant clone/24. Our results explain gene mutation and expression level of pfmdr1 may be associated in mefloquine resistance mechanism.

Original languageEnglish
Title of host publicationNucleic acids research. Supplement (2001)
Pages223-224
Number of pages2
Edition2
Publication statusPublished - 2002

Fingerprint

Mefloquine
Plasmodium falciparum
Clone Cells
Mutation
Quinine
Chloroquine
Drug Resistance
Genes
Gene Expression
Messenger RNA
Pharmaceutical Preparations

Cite this

Begum, K., Kim, H-S., Okuda, Y., Wataya, Y., Kimura, M., & Huruta, T. (2002). Genomic analysis of mefloquine-resistant Plasmodium falciparum. In Nucleic acids research. Supplement (2001) (2 ed., pp. 223-224)

Genomic analysis of mefloquine-resistant Plasmodium falciparum. / Begum, Khurshida; Kim, Hye-Sook; Okuda, Yohei; Wataya, Yusuke; Kimura, Mikio; Huruta, Takahisa.

Nucleic acids research. Supplement (2001). 2. ed. 2002. p. 223-224.

Research output: Chapter in Book/Report/Conference proceedingChapter

Begum, K, Kim, H-S, Okuda, Y, Wataya, Y, Kimura, M & Huruta, T 2002, Genomic analysis of mefloquine-resistant Plasmodium falciparum. in Nucleic acids research. Supplement (2001). 2 edn, pp. 223-224.
Begum K, Kim H-S, Okuda Y, Wataya Y, Kimura M, Huruta T. Genomic analysis of mefloquine-resistant Plasmodium falciparum. In Nucleic acids research. Supplement (2001). 2 ed. 2002. p. 223-224
Begum, Khurshida ; Kim, Hye-Sook ; Okuda, Yohei ; Wataya, Yusuke ; Kimura, Mikio ; Huruta, Takahisa. / Genomic analysis of mefloquine-resistant Plasmodium falciparum. Nucleic acids research. Supplement (2001). 2. ed. 2002. pp. 223-224
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