Genomic analysis of mefloquine-resistant Plasmodium falciparum.

Khurshida Begum, Hye Sook Kim, Yohei Okuda, Yusuke Wataya, Mikio Kimura, Takahisa Huruta

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5 Citations (Scopus)

Abstract

We studied sequence polymorphism, expression level of pfmdr1 gene and drug sensitivity in mefloquine sensitive-strain as well as mefloquine-resistant clone/24 to understand underlying drug resistance mechanism. Mefloquine-resistant clone/24 exhibited decreased susceptibility to mefloquine, quinine, halofantrine and artemisinin and increased susceptibility to chloroquine. We analyzed sequence of pfmdr1 gene and found mutation in pfmdr1 on clone/24. Moreover, overexpression of mRNA level of pfmdr1 has been observed in mefloquine-resistant clone/24. Our results explain gene mutation and expression level of pfmdr1 may be associated in mefloquine resistance mechanism.

Original languageEnglish
Pages (from-to)223-224
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Begum, K., Kim, H. S., Okuda, Y., Wataya, Y., Kimura, M., & Huruta, T. (2002). Genomic analysis of mefloquine-resistant Plasmodium falciparum. Nucleic acids research. Supplement (2001), (2), 223-224.