Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle

Koji Kobayashi, R. Ogasawara, A. Tsutaki, K. Lee, E. Ochi, K. Nakazato

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Genetic strain-dependent reactivity to mechanical stimuli in rat skeletal muscle has not been examined. This study aimed to examine whether genetic strain-dependency is associated with reactivity in protein metabolism and the resultant muscle hypertrophy after isometric resistance training (RT). The right triceps of Sprague-Dawley (SD) and Wistar rats underwent 12 sessions of RT. After RT, a transition from the IIb to the IIx myosin heavy-chain isoform was observed in both strains. In SD rats, the lateral gastrocnemius muscle (LG) mass of the trained legs (TRN) was significantly higher than that of the control legs (CON) (7.8 %, P

Original languageEnglish
Pages (from-to)527-535
Number of pages9
JournalPhysiological Research
Volume61
Issue number5
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Resistance Training
Muscle Proteins
Hypertrophy
Skeletal Muscle
Sprague Dawley Rats
Leg
Myosin Heavy Chains
Wistar Rats
Protein Isoforms
Muscles
Proteins

Keywords

  • Muscle hypertrophy
  • Protein degradation
  • Protein synthesis
  • Rat strains
  • Resistance training

ASJC Scopus subject areas

  • Physiology

Cite this

Kobayashi, K., Ogasawara, R., Tsutaki, A., Lee, K., Ochi, E., & Nakazato, K. (2012). Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle. Physiological Research, 61(5), 527-535.

Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle. / Kobayashi, Koji; Ogasawara, R.; Tsutaki, A.; Lee, K.; Ochi, E.; Nakazato, K.

In: Physiological Research, Vol. 61, No. 5, 2012, p. 527-535.

Research output: Contribution to journalArticle

Kobayashi, K, Ogasawara, R, Tsutaki, A, Lee, K, Ochi, E & Nakazato, K 2012, 'Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle', Physiological Research, vol. 61, no. 5, pp. 527-535.
Kobayashi, Koji ; Ogasawara, R. ; Tsutaki, A. ; Lee, K. ; Ochi, E. ; Nakazato, K. / Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle. In: Physiological Research. 2012 ; Vol. 61, No. 5. pp. 527-535.
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