TY - JOUR
T1 - Genetic risk factors for periodontitis in a Japanese population
AU - Kobayashi, T.
AU - Nagata, T.
AU - Murakami, S.
AU - Takashiba, S.
AU - Kurihara, H.
AU - Izumi, Y.
AU - Numabe, Y.
AU - Watanabe, H.
AU - Kataoka, M.
AU - Nagai, A.
AU - Hayashi, J.
AU - Ohyama, H.
AU - Okamatsu, Y.
AU - Inagaki, Y.
AU - Tai, H.
AU - Yoshie, H.
N1 - Funding Information:
Many thanks to the following, all of whom have contributed substantially to this work: Mari Adachi-Ogino (The University of Tokushima), Satoru Yamada, Takenori Nozaki (Osaka University), Koji Naruishi, Kazu Hatanaka, Yoshihiko Soga (Okayama University), Noriyoshi Mizuno, Miyuki Niitani (Hiroshima University), Toshiaki Nakamura (Kagoshima University), Asami Suzuki (The Nippon Dental University), Tomohiko Gunji (Tokyo Medical and Dental University), Susumu Hashitani (Hyogo College of Medicine), Makoto Kobayashi, and Takashi Takiguchi (Showa University). We are also grateful to Toshikazu Yamaguchi (BML Corporation) for technical support in the genotyping. This study was supported by a Grant-in Aid for Scientific Research (16209062) from the Japan Society for the Promotion of Science (JSPS), Japan.
PY - 2009/12
Y1 - 2009/12
N2 - Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.
AB - Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.
KW - Genetic risk factor
KW - Japanese
KW - Periodontitis
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U2 - 10.1177/0022034509350037
DO - 10.1177/0022034509350037
M3 - Article
C2 - 19892918
AN - SCOPUS:70450168967
VL - 88
SP - 1137
EP - 1141
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 12
ER -