Genetic risk factors for periodontitis in a Japanese population

T. Kobayashi, T. Nagata, S. Murakami, S. Takashiba, H. Kurihara, Y. Izumi, Y. Numabe, H. Watanabe, M. Kataoka, A. Nagai, J. Hayashi, H. Ohyama, Y. Okamatsu, Y. Inagaki, H. Tai, H. Yoshie

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18 Citations (Scopus)

Abstract

Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.

Original languageEnglish
Pages (from-to)1137-1141
Number of pages5
JournalJournal of dental research
Volume88
Issue number12
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Genetic risk factor
  • Japanese
  • Periodontitis

ASJC Scopus subject areas

  • Dentistry(all)

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    Kobayashi, T., Nagata, T., Murakami, S., Takashiba, S., Kurihara, H., Izumi, Y., Numabe, Y., Watanabe, H., Kataoka, M., Nagai, A., Hayashi, J., Ohyama, H., Okamatsu, Y., Inagaki, Y., Tai, H., & Yoshie, H. (2009). Genetic risk factors for periodontitis in a Japanese population. Journal of dental research, 88(12), 1137-1141. https://doi.org/10.1177/0022034509350037