Abstract
Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.
| Original language | English |
|---|---|
| Pages (from-to) | 1137-1141 |
| Number of pages | 5 |
| Journal | Journal of Dental Research |
| Volume | 88 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2009 |
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Keywords
- Genetic risk factor
- Japanese
- Periodontitis
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Genetic risk factors for periodontitis in a Japanese population. / Kobayashi, T.; Nagata, T.; Murakami, S.; Takashiba, Shogo; Kurihara, H.; Izumi, Y.; Numabe, Y.; Watanabe, H.; Kataoka, M.; Nagai, A.; Hayashi, J.; Ohyama, H.; Okamatsu, Y.; Inagaki, Y.; Tai, H.; Yoshie, H.
In: Journal of Dental Research, Vol. 88, No. 12, 12.2009, p. 1137-1141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic risk factors for periodontitis in a Japanese population
AU - Kobayashi, T.
AU - Nagata, T.
AU - Murakami, S.
AU - Takashiba, Shogo
AU - Kurihara, H.
AU - Izumi, Y.
AU - Numabe, Y.
AU - Watanabe, H.
AU - Kataoka, M.
AU - Nagai, A.
AU - Hayashi, J.
AU - Ohyama, H.
AU - Okamatsu, Y.
AU - Inagaki, Y.
AU - Tai, H.
AU - Yoshie, H.
PY - 2009/12
Y1 - 2009/12
N2 - Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.
AB - Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with periodontitis (172 aggressive and 147 chronic disease) and 303 race-matched healthy control individuals. Thirty-five functional gene polymorphisms that had been previously associated with immune responses were genotyped. For all gene polymorphisms tested, no significant differences were observed in the allele frequencies of persons with aggressive, chronic, and combined (aggressive and chronic) periodontitis, compared with control individuals. Multiple logistic regression analysis revealed a significant association of the vitamin D receptor +1056 T/C polymorphism with susceptibility to chronic periodontitis, after adjustment for age, gender, and smoking status (P = 0.002). These results suggest that none of the polymorphisms tested was strongly associated with periodontitis in a Japanese population. However, the vitamin D receptor +1056 polymorphism may be related to chronic periodontitis.
KW - Genetic risk factor
KW - Japanese
KW - Periodontitis
UR - http://www.scopus.com/inward/record.url?scp=70450168967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70450168967&partnerID=8YFLogxK
U2 - 10.1177/0022034509350037
DO - 10.1177/0022034509350037
M3 - Article
C2 - 19892918
AN - SCOPUS:70450168967
VL - 88
SP - 1137
EP - 1141
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 12
ER -