Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma

Yukiko Yasuda, Akiko Sakai, Sachio Itou, Yuichiro Mita, Takayuki Sonoyama, Shunsuke Tanabe, Yasuhiro Shirakawa, Yoshio Naomoto, Hiroshi Katayama, Kenji Shimizu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/ day) with the Arg/Arg genotype (OR=2.83, 95% CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.

Original languageEnglish
Pages (from-to)58-66
Number of pages9
JournalInternational Journal of Molecular Epidemiology and Genetics
Volume7
Issue number1
Publication statusPublished - 2016

Fingerprint

Genetic Polymorphisms
Codon
Genotype
Ethanol
cdc Genes
Schizosaccharomyces
Alcohol Drinking
DNA Damage
Single Nucleotide Polymorphism
Case-Control Studies
Japan
Smoking
History
Odds Ratio
Esophageal Squamous Cell Carcinoma
Neoplasms

Keywords

  • DNA damage
  • Esophageal squamous cell carcinoma
  • Human RAD17
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)
  • Genetics

Cite this

Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma. / Yasuda, Yukiko; Sakai, Akiko; Itou, Sachio; Mita, Yuichiro; Sonoyama, Takayuki; Tanabe, Shunsuke; Shirakawa, Yasuhiro; Naomoto, Yoshio; Katayama, Hiroshi; Shimizu, Kenji.

In: International Journal of Molecular Epidemiology and Genetics, Vol. 7, No. 1, 2016, p. 58-66.

Research output: Contribution to journalArticle

@article{6d78284b980c4f1dba350c152d434edc,
title = "Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma",
abstract = "Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95{\%} CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/ day) with the Arg/Arg genotype (OR=2.83, 95{\%} CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.",
keywords = "DNA damage, Esophageal squamous cell carcinoma, Human RAD17, Single nucleotide polymorphism",
author = "Yukiko Yasuda and Akiko Sakai and Sachio Itou and Yuichiro Mita and Takayuki Sonoyama and Shunsuke Tanabe and Yasuhiro Shirakawa and Yoshio Naomoto and Hiroshi Katayama and Kenji Shimizu",
year = "2016",
language = "English",
volume = "7",
pages = "58--66",
journal = "International Journal of Molecular Epidemiology and Genetics",
issn = "1948-1756",
publisher = "e-Century Publishing Corporation",
number = "1",

}

TY - JOUR

T1 - Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma

AU - Yasuda, Yukiko

AU - Sakai, Akiko

AU - Itou, Sachio

AU - Mita, Yuichiro

AU - Sonoyama, Takayuki

AU - Tanabe, Shunsuke

AU - Shirakawa, Yasuhiro

AU - Naomoto, Yoshio

AU - Katayama, Hiroshi

AU - Shimizu, Kenji

PY - 2016

Y1 - 2016

N2 - Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/ day) with the Arg/Arg genotype (OR=2.83, 95% CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.

AB - Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/ day) with the Arg/Arg genotype (OR=2.83, 95% CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.

KW - DNA damage

KW - Esophageal squamous cell carcinoma

KW - Human RAD17

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84962424438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962424438&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84962424438

VL - 7

SP - 58

EP - 66

JO - International Journal of Molecular Epidemiology and Genetics

JF - International Journal of Molecular Epidemiology and Genetics

SN - 1948-1756

IS - 1

ER -