TY - JOUR
T1 - Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma
AU - Yasuda, Yukiko
AU - Sakai, Akiko
AU - Ito, Sachio
AU - Mita, Yuichiro
AU - Sonoyama, Takayuki
AU - Tanabe, Shunsuke
AU - Shirakawa, Yasuhiro
AU - Naomoto, Yoshio
AU - Katayama, Hiroshi
AU - Shimizu, Kenji
N1 - Funding Information:
This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (grant no.12213084), and partially supported by the Smoking Research Foundation (K. S.). We appreciate Drs. Ouchida M., Kanzaki T., and Koide N. (Okayama University School of Medicine), Kusaka Y. (Kusaka Hospital, Bizen, Okayama), Hamanishi S. and Senoh E. (Junpukai Health Maintenance Center, Okayama) for their generous help in this study.
Publisher Copyright:
© 2016, E-Century Publishing Corporation. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/ day) with the Arg/Arg genotype (OR=2.83, 95% CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.
AB - Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/ day) with the Arg/Arg genotype (OR=2.83, 95% CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.
KW - DNA damage
KW - Esophageal squamous cell carcinoma
KW - Human RAD17
KW - Single nucleotide polymorphism
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M3 - Article
AN - SCOPUS:84962424438
SN - 1948-1756
VL - 7
SP - 58
EP - 66
JO - International Journal of Molecular Epidemiology and Genetics
JF - International Journal of Molecular Epidemiology and Genetics
IS - 1
ER -
