Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization

Toshihumi Ozaki, D. Wai, K. L. Schaefer, G. Goshager, W. Boecker, W. Winkelmann, B. Dockhorn-Dworniczak, Ch Poremba

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

There have been no reports on choromosomal aberrations of benign bone tumors revealed by comparative genomic hybridization (CGH). CGH analysis of benign tumors may be useful in understanding the mechanism of tumorigenesis with comparisons to malignant tumors. There were 4 tumors (2 enchondromas, one chondromyxoid fibroma, and one osteoid osteoma) and 8 tumor-like conditions (4 aneurysmal bone cysts (ABCs), one eosinophilic granuloma, one fibrous dysplasia, one solitary bone cyst, and one Rosai-Dorfman disease) available for analysis. One of 2 enchondromas and one of 4 ABCs exhibited rapid growth. Six lesions showed chromosomal aberrations, while 6 others did not. The most frequent aberrations were the loss of a whole chromosome-19 in 6 cases, the loss of chromosome-arm 22q in 4 cases, and the loss of chromosome-arm 17p in 3 cases. Gains were seen in 13q21 in 2 cartilaginous tumors and at 12q15-q21 in eosinophilic granulomas. Therefore, in benign bone tumors or tumor-like lesions, chromosomal aberrations are not frequent; however, some clear tendencies of clustering of aberrations can be observed.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalNeoplasma
Volume51
Issue number6
Publication statusPublished - 2004

Fingerprint

Comparative Genomic Hybridization
Bone and Bones
Neoplasms
Aneurysmal Bone Cysts
Chondroma
Eosinophilic Granuloma
Bone Cysts
Chromosome Aberrations
Chromosomes
Sinus Histiocytosis
Osteoid Osteoma
Chromosomes, Human, Pair 19
Fibroma
Cluster Analysis
Carcinogenesis
Growth

Keywords

  • Benign tumors
  • Chromosomal aberrations
  • Genetic imbalance
  • Genomic hybridization

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ozaki, T., Wai, D., Schaefer, K. L., Goshager, G., Boecker, W., Winkelmann, W., ... Poremba, C. (2004). Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization. Neoplasma, 51(6), 456-459.

Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization. / Ozaki, Toshihumi; Wai, D.; Schaefer, K. L.; Goshager, G.; Boecker, W.; Winkelmann, W.; Dockhorn-Dworniczak, B.; Poremba, Ch.

In: Neoplasma, Vol. 51, No. 6, 2004, p. 456-459.

Research output: Contribution to journalArticle

Ozaki, T, Wai, D, Schaefer, KL, Goshager, G, Boecker, W, Winkelmann, W, Dockhorn-Dworniczak, B & Poremba, C 2004, 'Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization', Neoplasma, vol. 51, no. 6, pp. 456-459.
Ozaki T, Wai D, Schaefer KL, Goshager G, Boecker W, Winkelmann W et al. Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization. Neoplasma. 2004;51(6):456-459.
Ozaki, Toshihumi ; Wai, D. ; Schaefer, K. L. ; Goshager, G. ; Boecker, W. ; Winkelmann, W. ; Dockhorn-Dworniczak, B. ; Poremba, Ch. / Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization. In: Neoplasma. 2004 ; Vol. 51, No. 6. pp. 456-459.
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