Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit

Masanori Komatsu; Ken Ichi Yamamoto; Hitoshi Mikami; James M. Sodetz

doi:10.1007/BF00590107

Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit

Masanori Komatsu, Ken Ichi Yamamoto, Hitoshi Mikami, James M. Sodetz

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)⁺RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)⁺RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Biochemical Genetics
Volume	29
Issue number	5-6
DOIs	https://doi.org/10.1007/BF00590107
Publication status	Published - Jun 1 1991

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Keywords

C8α-γ deficiency
complement
molecular basis
rabbit

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry
Molecular Biology
Genetics

Cite this

Komatsu, M., Yamamoto, K. I., Mikami, H., & Sodetz, J. M. (1991). Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit. Biochemical Genetics, 29(5-6), 271-274. https://doi.org/10.1007/BF00590107

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10.1007/BF00590107