Abstract
We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.
Original language | English |
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Pages (from-to) | 271-274 |
Number of pages | 4 |
Journal | Biochemical Genetics |
Volume | 29 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - Jun 1991 |
Externally published | Yes |
Keywords
- C8α-γ deficiency
- complement
- molecular basis
- rabbit
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Biochemistry
- Molecular Biology
- Genetics