Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit

Masanori Komatsu, Ken-ichi Yamamoto, Hitoshi Mikami, James M. Sodetz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalBiochemical Genetics
Volume29
Issue number5-6
DOIs
Publication statusPublished - Jun 1991
Externally publishedYes

Fingerprint

Complement C8
defect
RNA
complement
rabbits
Rabbits
Messenger RNA
Defects
messenger RNA
Complementary DNA
probe

Keywords

  • C8α-γ deficiency
  • complement
  • molecular basis
  • rabbit

ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Cite this

Genetic deficiency of complement component C8 in the rabbit : Evidence of a translational defect in expression of the α-γ subunit. / Komatsu, Masanori; Yamamoto, Ken-ichi; Mikami, Hitoshi; Sodetz, James M.

In: Biochemical Genetics, Vol. 29, No. 5-6, 06.1991, p. 271-274.

Research output: Contribution to journalArticle

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