Abstract
We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.
| Original language | English |
|---|---|
| Pages (from-to) | 271-274 |
| Number of pages | 4 |
| Journal | Biochemical Genetics |
| Volume | 29 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - Jun 1 1991 |
| Externally published | Yes |
Keywords
- C8α-γ deficiency
- complement
- molecular basis
- rabbit
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Biochemistry
- Molecular Biology
- Genetics
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Cite this
Komatsu, M., Yamamoto, K. I., Mikami, H., & Sodetz, J. M. (1991). Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit. Biochemical Genetics, 29(5-6), 271-274. https://doi.org/10.1007/BF00590107