Abstract
We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.
| Original language | English |
|---|---|
| Pages (from-to) | 271-274 |
| Number of pages | 4 |
| Journal | Biochemical Genetics |
| Volume | 29 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - Jun 1991 |
| Externally published | Yes |
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Keywords
- C8α-γ deficiency
- complement
- molecular basis
- rabbit
ASJC Scopus subject areas
- Genetics
- Biochemistry
Cite this
Genetic deficiency of complement component C8 in the rabbit : Evidence of a translational defect in expression of the α-γ subunit. / Komatsu, Masanori; Yamamoto, Ken-ichi; Mikami, Hitoshi; Sodetz, James M.
In: Biochemical Genetics, Vol. 29, No. 5-6, 06.1991, p. 271-274.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic deficiency of complement component C8 in the rabbit
T2 - Evidence of a translational defect in expression of the α-γ subunit
AU - Komatsu, Masanori
AU - Yamamoto, Ken-ichi
AU - Mikami, Hitoshi
AU - Sodetz, James M.
PY - 1991/6
Y1 - 1991/6
N2 - We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.
AB - We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.
KW - C8α-γ deficiency
KW - complement
KW - molecular basis
KW - rabbit
UR - http://www.scopus.com/inward/record.url?scp=0025913309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025913309&partnerID=8YFLogxK
U2 - 10.1007/BF00590107
DO - 10.1007/BF00590107
M3 - Article
C2 - 1772398
AN - SCOPUS:0025913309
VL - 29
SP - 271
EP - 274
JO - Biochemical Genetics
JF - Biochemical Genetics
SN - 0006-2928
IS - 5-6
ER -