Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit

Masanori Komatsu; Ken Ichi Yamamoto; Hitoshi Mikami; James M. Sodetz

doi:10.1007/BF00590107

Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit

Masanori Komatsu, Ken Ichi Yamamoto, Hitoshi Mikami, James M. Sodetz

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)⁺RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)⁺RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.

Original language	English
Pages (from-to)	271-274
Number of pages	4
Journal	Biochemical Genetics
Volume	29
Issue number	5-6
DOIs	https://doi.org/10.1007/BF00590107
Publication status	Published - Jun 1991
Externally published	Yes

Keywords

C8α-γ deficiency
complement
molecular basis
rabbit

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry
Molecular Biology
Genetics

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10.1007/BF00590107

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title = "Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit",

abstract = "We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.",

keywords = "C8α-γ deficiency, complement, molecular basis, rabbit",

author = "Masanori Komatsu and Yamamoto, {Ken Ichi} and Hitoshi Mikami and Sodetz, {James M.}",

year = "1991",

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T1 - Genetic deficiency of complement component C8 in the rabbit

T2 - Evidence of a translational defect in expression of the α-γ subunit

AU - Komatsu, Masanori

AU - Yamamoto, Ken Ichi

AU - Mikami, Hitoshi

AU - Sodetz, James M.

PY - 1991/6

Y1 - 1991/6

N2 - We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.

AB - We examined the molecular basis for rabbit C8α-γ deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for α, β, and γ, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for α and γ of the same size and amounts as normal rabbits. Thus, C8α-γ deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.

KW - C8α-γ deficiency

KW - complement

KW - molecular basis

KW - rabbit

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JO - Biochemical Genetics

JF - Biochemical Genetics

SN - 0006-2928

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ER -

Genetic deficiency of complement component C8 in the rabbit: Evidence of a translational defect in expression of the α-γ subunit

Abstract

Keywords

ASJC Scopus subject areas

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