TY - JOUR
T1 - Genetic association between susceptibility to Parkinson's disease and α1-antichymotrypsin polymorphism
AU - Yamamoto, Mitsutoshi
AU - Kondo, Ikuko
AU - Ogawa, Norio
AU - Asanuma, Masato
AU - Yamashita, Yoshiaki
AU - Mizuno, Yoshikuni
N1 - Funding Information:
This study was supported by in part by a Grant-in-Aid for Scientific Research in Priority Area from the Ministry of Education, Science, Sports and Culture, Japan and a Grant from the Research Committee for Neurodegenerative Diseases, the Ministry of Health and Welfare, Japan.
PY - 1997/6/6
Y1 - 1997/6/6
N2 - The apolipoprotein E (ApoE) gene is a major risk factor of developing Alzheimer's disease (AD) and the α1-antichymotrypsin (ACT) polymorphism is likely to modify susceptibility of the ApoE gene for AD. Because pathogenesis of AD is partly similar to that in idiopathic Parkinson's disease (PD), we investigated the distribution of genotypes of the ApoE and the ACT in patients with PD. The number of individuals with two copies of the ACT-A allele (ACT-AA genotype) in patients with PD increased significantly compared to that in healthy controls (19.9% versus 8.3%, P < 0.02), and the ACT-A allele frequency in patients with PD was significantly higher than that in healthy controls (X2 = 5.96, df = 1, P < 0.015). The odds ratio for developing PD in individuals with the ACT-AA genotype was 3.36 compared to individuals with two copies of another allele, the ACT-T allele (ACT-TT genotype). There was no association between ApoE genotypes and susceptibility to PD. These data suggest that the etiological basis of PD might be partly similar to that of AD and the ACT gene might be one of the susceptibility factors for PD.
AB - The apolipoprotein E (ApoE) gene is a major risk factor of developing Alzheimer's disease (AD) and the α1-antichymotrypsin (ACT) polymorphism is likely to modify susceptibility of the ApoE gene for AD. Because pathogenesis of AD is partly similar to that in idiopathic Parkinson's disease (PD), we investigated the distribution of genotypes of the ApoE and the ACT in patients with PD. The number of individuals with two copies of the ACT-A allele (ACT-AA genotype) in patients with PD increased significantly compared to that in healthy controls (19.9% versus 8.3%, P < 0.02), and the ACT-A allele frequency in patients with PD was significantly higher than that in healthy controls (X2 = 5.96, df = 1, P < 0.015). The odds ratio for developing PD in individuals with the ACT-AA genotype was 3.36 compared to individuals with two copies of another allele, the ACT-T allele (ACT-TT genotype). There was no association between ApoE genotypes and susceptibility to PD. These data suggest that the etiological basis of PD might be partly similar to that of AD and the ACT gene might be one of the susceptibility factors for PD.
KW - Alzheimer's disease
KW - ApoE genotype
KW - Dementia
KW - Genetic association
KW - Parkinson's disease
KW - α-Antichymotrypsin polymorphism
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U2 - 10.1016/S0006-8993(97)00330-2
DO - 10.1016/S0006-8993(97)00330-2
M3 - Article
C2 - 9219874
AN - SCOPUS:0030749516
VL - 759
SP - 153
EP - 155
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -