Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer

Lisheng Chen, Nagahide Matsubara, Tadashi Yoshino, Takeshi Nagasaka, Naoko Hoshizima, Yasuhiro Shirakawa, Yoshio Naomoto, Hiroshi Isozaki, Karl Riabowol, Noriaki Tanaka

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

Overexpression of ING1, a candidate tumor suppressor gene, efficiently blocks cell growth or induces apoptosis in different experimental systems. ING1 maps to chromosome 13q33-34, and because loss of the terminal region of chromosome 13q has been implicated in esophageal squamous cell cancer (ESCC), we examined ESCC for genetic alterations of ING1. Among 31 informative cases of ESCC, 58.9% of the tumors showed allelic loss at chromosome 13q33-34, and we detected four tumor-specific missense nucleotide changes. These alterations were found within the PHD finger domain and nuclear localization motif of the ING1 and may be functionally involved in the development of ESCC. Because immunohistochemical study revealed that all of the ESCC samples showed loss of ING1 protein expression, genetic or epigenetic alterations that abrogate the normal function of ING1 may contribute to esophageal squamous cell carcinogenesis.

Original languageEnglish
Pages (from-to)4345-4349
Number of pages5
JournalCancer Research
Volume61
Issue number11
Publication statusPublished - Jun 1 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer'. Together they form a unique fingerprint.

Cite this