Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites

Theodore F. Taraschi, Megan O'Donnell, Sandra Martinez, Timothy Schneider, Darin Trelka, Velia M. Fowler, Leann Tilley, Yoshinori Moriyama

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane.

Original languageEnglish
Pages (from-to)3420-3426
Number of pages7
JournalBlood
Volume102
Issue number9
DOIs
Publication statusPublished - Nov 1 2003
Externally publishedYes

Fingerprint

Transport Vesicles
Falciparum Malaria
N-Ethylmaleimide-Sensitive Proteins
Parasites
Erythrocytes
Erythrocyte Membrane
Cytosol
Cell membranes
Cell Membrane
Coated Vesicles
Proteins
Plasmodium
Golgi Apparatus
Plasmodium falciparum
Myosins
GTP-Binding Proteins
Endoplasmic Reticulum
Actins
Membranes
Chemical activation

ASJC Scopus subject areas

  • Hematology

Cite this

Taraschi, T. F., O'Donnell, M., Martinez, S., Schneider, T., Trelka, D., Fowler, V. M., ... Moriyama, Y. (2003). Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites. Blood, 102(9), 3420-3426. https://doi.org/10.1182/blood-2003-05-1448

Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites. / Taraschi, Theodore F.; O'Donnell, Megan; Martinez, Sandra; Schneider, Timothy; Trelka, Darin; Fowler, Velia M.; Tilley, Leann; Moriyama, Yoshinori.

In: Blood, Vol. 102, No. 9, 01.11.2003, p. 3420-3426.

Research output: Contribution to journalArticle

Taraschi, TF, O'Donnell, M, Martinez, S, Schneider, T, Trelka, D, Fowler, VM, Tilley, L & Moriyama, Y 2003, 'Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites', Blood, vol. 102, no. 9, pp. 3420-3426. https://doi.org/10.1182/blood-2003-05-1448
Taraschi TF, O'Donnell M, Martinez S, Schneider T, Trelka D, Fowler VM et al. Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites. Blood. 2003 Nov 1;102(9):3420-3426. https://doi.org/10.1182/blood-2003-05-1448
Taraschi, Theodore F. ; O'Donnell, Megan ; Martinez, Sandra ; Schneider, Timothy ; Trelka, Darin ; Fowler, Velia M. ; Tilley, Leann ; Moriyama, Yoshinori. / Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites. In: Blood. 2003 ; Vol. 102, No. 9. pp. 3420-3426.
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