Generation and reaction of copper(I) hydride in the copper(I) chloride-tributyltin hydride-NMP system: Synthesis of 3-norcephalosporin

Hideo Tanaka, Yoshihiko Yamaguchi, Shin Ichi Sumida, Manabu Kuroboshi, Misato Mochizuki, Sigeru Torii

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9 Citations (Scopus)

Abstract

Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.

Original languageEnglish
Pages (from-to)3463-3468
Number of pages6
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number23
Publication statusPublished - Dec 7 1999

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ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry

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