Abstract
Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 3463-3468 |
| Number of pages | 6 |
| Journal | Journal of the Chemical Society, Perkin Transactions 1 |
| Issue number | 23 |
| Publication status | Published - Dec 7 1999 |
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ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
Cite this
Generation and reaction of copper(I) hydride in the copper(I) chloride-tributyltin hydride-NMP system : Synthesis of 3-norcephalosporin. / Tanaka, Hideo; Yamaguchi, Yoshihiko; Sumida, Shin Ichi; Kuroboshi, Manabu; Mochizuki, Misato; Torii, Sigeru.
In: Journal of the Chemical Society, Perkin Transactions 1, No. 23, 07.12.1999, p. 3463-3468.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Generation and reaction of copper(I) hydride in the copper(I) chloride-tributyltin hydride-NMP system
T2 - Synthesis of 3-norcephalosporin
AU - Tanaka, Hideo
AU - Yamaguchi, Yoshihiko
AU - Sumida, Shin Ichi
AU - Kuroboshi, Manabu
AU - Mochizuki, Misato
AU - Torii, Sigeru
PY - 1999/12/7
Y1 - 1999/12/7
N2 - Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.
AB - Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0042936049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042936049&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0042936049
SP - 3463
EP - 3468
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
SN - 1472-7781
IS - 23
ER -