TY - JOUR
T1 - Generation and reaction of copper(I) hydride in the copper(I) chloride-tributyltin hydride-NMP system
T2 - Synthesis of 3-norcephalosporin
AU - Tanaka, Hideo
AU - Yamaguchi, Yoshihiko
AU - Sumida, Shin Ichi
AU - Kuroboshi, Manabu
AU - Mochizuki, Misato
AU - Torii, Sigeru
PY - 1999/12/7
Y1 - 1999/12/7
N2 - Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.
AB - Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.
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U2 - 10.1039/a907049d
DO - 10.1039/a907049d
M3 - Article
AN - SCOPUS:0042936049
SP - 3463
EP - 3468
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
SN - 1472-7781
IS - 23
ER -