Abstract
Synthesis of 3-norcephalosporin 1 was performed successfully by reaction of either 3-trifluoromethylsulfonyloxy-Δ3-cephem 2, allenecarboxylate 3 or 3,4-disubstitued but-2-enoates 4 with copper(I) chloride and tributyltin hydride in N-methylpyrrolidin-2-one (NMP). Generation and reactions of a copper(I) hydride species in the copper(I) chloride-tributyltin hydride-NMP or N,N-dimethylformamide (DMF) system are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 3463-3468 |
| Number of pages | 6 |
| Journal | Journal of the Chemical Society - Perkin Transactions 1 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Dec 7 1999 |
ASJC Scopus subject areas
- Chemistry(all)
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Tanaka, H., Yamaguchi, Y., Sumida, S. I., Kuroboshi, M., Mochizuki, M., & Torii, S. (1999). Generation and reaction of copper(I) hydride in the copper(I) chloride-tributyltin hydride-NMP system: Synthesis of 3-norcephalosporin. Journal of the Chemical Society - Perkin Transactions 1, (23), 3463-3468. https://doi.org/10.1039/a907049d