Generalized arteriosclerosis and changes of the cochlea in young adults

Rie Nomiya, Shigenobu Nomiya, Shin Kariya, Mitsuhiro Okano, Norimasa Morita, Sebahattin Cureoglu, Patricia A. Schachern, Kazunori Nishizaki, Michael M. Paparella

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Hypothesis: To disclose the histopathologic findings of the cochlea in young adults with generalized arteriosclerosis. Background: It is well known that arteriosclerosis begins and progresses during childhood. Although the relationship between arteriosclerosis and auditory function in elderly people was examined in many reports, the histopathologic effect of arteriosclerosis on the cochlea in young adults has not been studied. Methods: This study involved quantitative analysis, including the number of spiral ganglion cells, the loss of cochlear outer hair cells, and the areas of stria vascularis and spiral ligament. It included 10 temporal bones from 6 subjects with generalized arteriosclerosis and 10 age-matched normal control temporal bones from 7 subjects. Results: The mean number of spiral ganglion cells in the cochlea with generalized arteriosclerosis was significantly lower than that in normal controls in the basal turn. The mean loss of outer hair cells in the cochlea with generalized arteriosclerosis was significantly greater than that of normal controls in the basal and apical turns. The stria vascularis and spiral ligament were severely atrophic, with generalized arteriosclerosis in the basal turn. There was no significant difference in the thickness of the spiral modiolar artery between generalized arteriosclerosis and normal controls. Conclusion: Degeneration of the cochlea, especially in the basal turn, was already apparent in young adults with generalized arteriosclerosis.

Original languageEnglish
Pages (from-to)1193-1197
Number of pages5
JournalOtology and Neurotology
Volume29
Issue number8
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Arteriosclerosis
Cochlea
Young Adult
Outer Auditory Hair Cells
Spiral Ligament of Cochlea
Stria Vascularis
Spiral Ganglion
Temporal Bone
Arteries

Keywords

  • Arteriosclerosis
  • Cochlea
  • Human temporal bone

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Sensory Systems
  • Medicine(all)

Cite this

Nomiya, R., Nomiya, S., Kariya, S., Okano, M., Morita, N., Cureoglu, S., ... Paparella, M. M. (2008). Generalized arteriosclerosis and changes of the cochlea in young adults. Otology and Neurotology, 29(8), 1193-1197. https://doi.org/10.1097/MAO.0b013e31818a0906

Generalized arteriosclerosis and changes of the cochlea in young adults. / Nomiya, Rie; Nomiya, Shigenobu; Kariya, Shin; Okano, Mitsuhiro; Morita, Norimasa; Cureoglu, Sebahattin; Schachern, Patricia A.; Nishizaki, Kazunori; Paparella, Michael M.

In: Otology and Neurotology, Vol. 29, No. 8, 12.2008, p. 1193-1197.

Research output: Contribution to journalArticle

Nomiya, R, Nomiya, S, Kariya, S, Okano, M, Morita, N, Cureoglu, S, Schachern, PA, Nishizaki, K & Paparella, MM 2008, 'Generalized arteriosclerosis and changes of the cochlea in young adults', Otology and Neurotology, vol. 29, no. 8, pp. 1193-1197. https://doi.org/10.1097/MAO.0b013e31818a0906
Nomiya, Rie ; Nomiya, Shigenobu ; Kariya, Shin ; Okano, Mitsuhiro ; Morita, Norimasa ; Cureoglu, Sebahattin ; Schachern, Patricia A. ; Nishizaki, Kazunori ; Paparella, Michael M. / Generalized arteriosclerosis and changes of the cochlea in young adults. In: Otology and Neurotology. 2008 ; Vol. 29, No. 8. pp. 1193-1197.
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