Gene transfer to the retina of rat by liposome eye drops

Toshihiko Matsuo, Ikuya Masuda, Tatsuji Yasuda, Nobuhiko Matsuo

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Gene delivery to the intraocular tissues of the retina is hampered by complicated surgical interventions to administer the gene. Here we showed that instillation as eye drops of an expression plasmid vector for beta-galactosidase gene carried by the specific kinds of liposomes could transfer the gene to the retinal ganglion cells of rat, without causing any inflammation. This non-surgical, convenient way for gene delivery to the retina would facilitate the development of treatment for various intraocular diseases.

Original languageEnglish
Pages (from-to)947-950
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume219
Issue number3
DOIs
Publication statusPublished - Feb 27 1996

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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