Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

T. Noda, H. Takaki, T. Kurita, K. Suyama, N. Nagaya, A. Taguchi, N. Aihara, S. Kamakura, K. Sunagawa, Kazufumi Nakamura, T. Ohe, M. Horie, C. Napolitano, J. A. Towbin, S. G. Priori, Wataru Shimizu

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Abstract

Aims: Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome. Methods and Results: We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0·1 μg . kg-1 of epinephrine followed by continuous infusion (0·1 μg · kg-1 min-1) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477±42 to 631± 59 ms; P

Original languageEnglish
Pages (from-to)975-983
Number of pages9
JournalEuropean Heart Journal
Volume23
Issue number12
DOIs
Publication statusPublished - Jun 2002

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Keywords

  • Action potentials
  • Catecholamines
  • Genetics
  • Long-QT syndrome
  • Nervous system
  • Sympathetic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Noda, T., Takaki, H., Kurita, T., Suyama, K., Nagaya, N., Taguchi, A., Aihara, N., Kamakura, S., Sunagawa, K., Nakamura, K., Ohe, T., Horie, M., Napolitano, C., Towbin, J. A., Priori, S. G., & Shimizu, W. (2002). Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. European Heart Journal, 23(12), 975-983. https://doi.org/10.1053/euhj.2001.3079