Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas

Takashi Oka, Mamoru Oouchida, Maho Koyama, Yoichiro Ogama, Shinichi Takada, Yoko Nakatani, Takehiro Tanaka, Tadashi Yoshino, Kazuhiko Hayashi, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Junjiro Tsuchiyama, Mitsune Tanimoto, Kenji Shimizu, Tadaatsu Akagi

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.

Original languageEnglish
Pages (from-to)6390-6394
Number of pages5
JournalCancer Research
Volume62
Issue number22
Publication statusPublished - Nov 15 2002

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Non-Receptor Type 6 Protein Tyrosine Phosphatase
Gene Silencing
Methylation
Tyrosine
Lymphoma
Leukemia
Genes
Loss of Heterozygosity
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Microsatellite Repeats
Observation
Cell Line
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Oka, T., Oouchida, M., Koyama, M., Ogama, Y., Takada, S., Nakatani, Y., ... Akagi, T. (2002). Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Research, 62(22), 6390-6394.

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. / Oka, Takashi; Oouchida, Mamoru; Koyama, Maho; Ogama, Yoichiro; Takada, Shinichi; Nakatani, Yoko; Tanaka, Takehiro; Yoshino, Tadashi; Hayashi, Kazuhiko; Ohara, Nobuya; Kondo, Eisaku; Takahashi, Kiyoshi; Tsuchiyama, Junjiro; Tanimoto, Mitsune; Shimizu, Kenji; Akagi, Tadaatsu.

In: Cancer Research, Vol. 62, No. 22, 15.11.2002, p. 6390-6394.

Research output: Contribution to journalArticle

Oka, T, Oouchida, M, Koyama, M, Ogama, Y, Takada, S, Nakatani, Y, Tanaka, T, Yoshino, T, Hayashi, K, Ohara, N, Kondo, E, Takahashi, K, Tsuchiyama, J, Tanimoto, M, Shimizu, K & Akagi, T 2002, 'Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas', Cancer Research, vol. 62, no. 22, pp. 6390-6394.
Oka, Takashi ; Oouchida, Mamoru ; Koyama, Maho ; Ogama, Yoichiro ; Takada, Shinichi ; Nakatani, Yoko ; Tanaka, Takehiro ; Yoshino, Tadashi ; Hayashi, Kazuhiko ; Ohara, Nobuya ; Kondo, Eisaku ; Takahashi, Kiyoshi ; Tsuchiyama, Junjiro ; Tanimoto, Mitsune ; Shimizu, Kenji ; Akagi, Tadaatsu. / Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. In: Cancer Research. 2002 ; Vol. 62, No. 22. pp. 6390-6394.
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