Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas

Takashi Oka; Mamoru Ouchida; Maho Koyama; Yoichiro Ogama; Shinichi Takada; Yoko Nakatani; Takehiro Tanaka; Tadashi Yoshino; Kazuhiko Hayashi; Nobuya Ohara; Eisaku Kondo; Kiyoshi Takahashi; Junjiro Tsuchiyama; Mitsune Tanimoto; Kenji Shimizu; Tadaatsu Akagi

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas

Takashi Oka, Mamoru Ouchida, Maho Koyama, Yoichiro Ogama, Shinichi Takada, Yoko Nakatani, Takehiro Tanaka, Tadashi Yoshino, Kazuhiko Hayashi, Nobuya Ohara, Eisaku Kondo, Kiyoshi Takahashi, Junjiro Tsuchiyama, Mitsune Tanimoto, Kenji Shimizu, Tadaatsu Akagi

Research output: Contribution to journal › Article › peer-review

182 Citations (Scopus)

Abstract

High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.

Original language	English
Pages (from-to)	6390-6394
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	22
Publication status	Published - Nov 15 2002

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas",

abstract = "High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.",

author = "Takashi Oka and Mamoru Ouchida and Maho Koyama and Yoichiro Ogama and Shinichi Takada and Yoko Nakatani and Takehiro Tanaka and Tadashi Yoshino and Kazuhiko Hayashi and Nobuya Ohara and Eisaku Kondo and Kiyoshi Takahashi and Junjiro Tsuchiyama and Mitsune Tanimoto and Kenji Shimizu and Tadaatsu Akagi",

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journal = "Cancer Research",

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T1 - Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas

AU - Oka, Takashi

AU - Ouchida, Mamoru

AU - Koyama, Maho

AU - Ogama, Yoichiro

AU - Takada, Shinichi

AU - Nakatani, Yoko

AU - Tanaka, Takehiro

AU - Yoshino, Tadashi

AU - Hayashi, Kazuhiko

AU - Ohara, Nobuya

AU - Kondo, Eisaku

AU - Takahashi, Kiyoshi

AU - Tsuchiyama, Junjiro

AU - Tanimoto, Mitsune

AU - Shimizu, Kenji

AU - Akagi, Tadaatsu

PY - 2002/11/15

Y1 - 2002/11/15

N2 - High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.

AB - High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.

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Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas

Abstract

ASJC Scopus subject areas

UN SDGs

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