GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice

Isao Date, Mizuho Aoi, Susumu Tomita, Frank Collins, Takashi Ohmoto

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.

Original languageEnglish
Pages (from-to)2365-2369
Number of pages5
JournalNeuroReport
Volume9
Issue number10
Publication statusPublished - Jul 13 1998

Fingerprint

Glial Cell Line-Derived Neurotrophic Factor
Parkinson Disease
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Nerve Growth Factors
Transforming Growth Factors
Inbred C57BL Mouse
Neurodegenerative Diseases

Keywords

  • Ageing
  • Dopamine
  • GDNF
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice. / Date, Isao; Aoi, Mizuho; Tomita, Susumu; Collins, Frank; Ohmoto, Takashi.

In: NeuroReport, Vol. 9, No. 10, 13.07.1998, p. 2365-2369.

Research output: Contribution to journalArticle

Date, Isao ; Aoi, Mizuho ; Tomita, Susumu ; Collins, Frank ; Ohmoto, Takashi. / GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice. In: NeuroReport. 1998 ; Vol. 9, No. 10. pp. 2365-2369.
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