GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice

Isao Date, Mizuho Aoi, Susumu Tomita, Frank Collins, Takashi Ohmoto

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.

Original languageEnglish
Pages (from-to)2365-2369
Number of pages5
JournalNeuroReport
Volume9
Issue number10
DOIs
Publication statusPublished - Jul 13 1998

Keywords

  • Ageing
  • Dopamine
  • GDNF
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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