GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice

Isao Date; Mizuho Aoi; Susumu Tomita; Frank Collins; Takashi Ohmoto

doi:10.1097/00001756-199807130-00039

GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice

Isao Date, Mizuho Aoi, Susumu Tomita, Frank Collins, Takashi Ohmoto

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.

Original language	English
Pages (from-to)	2365-2369
Number of pages	5
Journal	NeuroReport
Volume	9
Issue number	10
DOIs	https://doi.org/10.1097/00001756-199807130-00039
Publication status	Published - Jul 13 1998

Keywords

Ageing
Dopamine
GDNF
Parkinson's disease

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199807130-00039

Cite this

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abstract = "Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.",

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AU - Aoi, Mizuho

AU - Tomita, Susumu

AU - Collins, Frank

AU - Ohmoto, Takashi

PY - 1998/7/13

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GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice

Abstract

Keywords

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