Abstract
Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.
| Original language | English |
|---|---|
| Pages (from-to) | 2365-2369 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 9 |
| Issue number | 10 |
| Publication status | Published - Jul 13 1998 |
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Keywords
- Ageing
- Dopamine
- GDNF
- Parkinson's disease
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice. / Date, Isao; Aoi, Mizuho; Tomita, Susumu; Collins, Frank; Ohmoto, Takashi.
In: NeuroReport, Vol. 9, No. 10, 13.07.1998, p. 2365-2369.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged Parkinsonian mice
AU - Date, Isao
AU - Aoi, Mizuho
AU - Tomita, Susumu
AU - Collins, Frank
AU - Ohmoto, Takashi
PY - 1998/7/13
Y1 - 1998/7/13
N2 - Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.
AB - Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor β super-family and acts as a neurotrophic factor for the nigrostriatal dopaminergic system. GDNF was injected stereotaxically into the striatum of young (2 months old) and aged (12 months old) C57BL/6 mice that were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1 week earlier. Immunocytochemical and neurochemical analyses showed significant recovery of the nigrostriatal dopaminergic system both in young and in aged mice. Since Parkinson's disease is a neurodegenerative disorder mainly affecting elderly people, this result demonstrates the potential usefulness of GDNF in treating Parkinson's disease.
KW - Ageing
KW - Dopamine
KW - GDNF
KW - Parkinson's disease
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UR - http://www.scopus.com/inward/citedby.url?scp=0032514206&partnerID=8YFLogxK
M3 - Article
C2 - 9694229
AN - SCOPUS:0032514206
VL - 9
SP - 2365
EP - 2369
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 10
ER -