Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey

Kenji Notohara, Terumi Kamisawa, Kazushige Uchida, Yoh Zen, Mitsuhiro Kawano, Satomi Kasashima, Yasuharu Sato, Masahiro Shiokawa, Takeshi Uehara, Hajime Yoshifuji, Hiroko Hayashi, Koichi Inoue, Keisuke Iwasaki, Hiroo Kawano, Hiroyuki Matsubayashi, Yukitoshi Moritani, Katsuhiko Murakawa, Yoshio Oka, Masatoshi Tateno, Kazuichi OkazakiTsutomu Chiba

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Several reports on immunoglobulin (Ig)G4-related disease (IgG4-RD) with gastrointestinal involvement (IgG4-related gastrointestinal disease; IgG4-GID) have been published, although this entity has not been fully established clinicopathologically. Thus, we carried out a multicenter survey. Methods: Patients with possible IgG4-GID who underwent resection were collected. Histologic slides were reevaluated, and eight cases with diffuse lymphoplasmacytic infiltration but without numerous neutrophils, granulations or epithelioid granulomas were further analyzed. Results: Overall, the IgG4 counts (87–345/high-power field) and IgG4/IgG-positive ratio were high (44–115%). The demographic findings included advanced age among the patients (55–80 years) and male preponderance (six cases). Six lesions (five gastric, one esophageal), consisting of lymphoplasmacytic infiltration with neural involvement in the muscularis propria and/or bottom-heavy plasmacytosis in the gastric mucosa, were histologically regarded as highly suggestive of IgG4-RD. Storiform fibrosis and obliterative phlebitis were found in two cases, and the former gave rise to a 7-cm-sized inflammatory pseudotumor (IPT) in one case. Ulceration and carcinoma co-existed in three and two lesions, respectively. All the patients had other organ involvement (OOI), and serum IgG4 levels were markedly elevated (four of five patients). The remaining two cases with gastric IPTs featuring reactive nodular fibrous pseudotumor or nodular lymphoid hyperplasia were regarded as possible cases of IgG4-RD because of the histologic findings and lack of OOI. Conclusions: IgG4-GID is found in the setting of IgG4-RD, often with ulceration or cancer. Characteristic histologic findings are observed in the muscularis propria and gastric mucosa. Cases with IPT may be heterogeneous, and there may be mimickers of IgG4-GID.

Original languageEnglish
Pages (from-to)845-853
Number of pages9
JournalJournal of Gastroenterology
Volume53
Issue number7
DOIs
Publication statusPublished - Jul 1 2018
Externally publishedYes

Keywords

  • Gastrointestinal tract
  • IgG4
  • IgG4-related disease
  • Inflammatory pseudotumor
  • Pathology

ASJC Scopus subject areas

  • Gastroenterology

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  • Cite this

    Notohara, K., Kamisawa, T., Uchida, K., Zen, Y., Kawano, M., Kasashima, S., Sato, Y., Shiokawa, M., Uehara, T., Yoshifuji, H., Hayashi, H., Inoue, K., Iwasaki, K., Kawano, H., Matsubayashi, H., Moritani, Y., Murakawa, K., Oka, Y., Tateno, M., ... Chiba, T. (2018). Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey. Journal of Gastroenterology, 53(7), 845-853. https://doi.org/10.1007/s00535-017-1420-4