Abstract
The lumbar spinal cord contains local neural circuits that are important in regulating male sexual behaviours, but the molecular mechanisms underlying these systems remain elusive. Gastrin-releasing peptide (GRP) is a member of the bombesin-like peptide family first isolated from the porcine stomach. Despite extensive pharmacological studies on the activity of bombesin-like peptides administered to mammals, little is known about the physiological functions of GRP in the spinal cord. We review recent findings on a system of neurones in the upper lumbar spinal cord, within the recently reported ejaculation generator, projecting axons containing GRP to the lower lumbar spinal cord and innervating regions known to control erection and ejaculation.
| Original language | English |
|---|---|
| Pages (from-to) | 432-435 |
| Number of pages | 4 |
| Journal | Journal of Neuroendocrinology |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
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Keywords
- Androgen
- Gastrin-releasing peptide
- Lumbar spinal cord
- Male sexual behaviour
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience
Cite this
Gastrin-releasing peptide system in the spinal cord controls male sexual behaviour. / Sakamoto, Hirotaka; Kawata, M.
In: Journal of Neuroendocrinology, Vol. 21, No. 4, 2009, p. 432-435.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastrin-releasing peptide system in the spinal cord controls male sexual behaviour
AU - Sakamoto, Hirotaka
AU - Kawata, M.
PY - 2009
Y1 - 2009
N2 - The lumbar spinal cord contains local neural circuits that are important in regulating male sexual behaviours, but the molecular mechanisms underlying these systems remain elusive. Gastrin-releasing peptide (GRP) is a member of the bombesin-like peptide family first isolated from the porcine stomach. Despite extensive pharmacological studies on the activity of bombesin-like peptides administered to mammals, little is known about the physiological functions of GRP in the spinal cord. We review recent findings on a system of neurones in the upper lumbar spinal cord, within the recently reported ejaculation generator, projecting axons containing GRP to the lower lumbar spinal cord and innervating regions known to control erection and ejaculation.
AB - The lumbar spinal cord contains local neural circuits that are important in regulating male sexual behaviours, but the molecular mechanisms underlying these systems remain elusive. Gastrin-releasing peptide (GRP) is a member of the bombesin-like peptide family first isolated from the porcine stomach. Despite extensive pharmacological studies on the activity of bombesin-like peptides administered to mammals, little is known about the physiological functions of GRP in the spinal cord. We review recent findings on a system of neurones in the upper lumbar spinal cord, within the recently reported ejaculation generator, projecting axons containing GRP to the lower lumbar spinal cord and innervating regions known to control erection and ejaculation.
KW - Androgen
KW - Gastrin-releasing peptide
KW - Lumbar spinal cord
KW - Male sexual behaviour
UR - http://www.scopus.com/inward/record.url?scp=63549096247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63549096247&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2826.2009.01847.x
DO - 10.1111/j.1365-2826.2009.01847.x
M3 - Article
C2 - 19187464
AN - SCOPUS:63549096247
VL - 21
SP - 432
EP - 435
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
SN - 0953-8194
IS - 4
ER -