Gastrin-releasing peptide

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The hastrin-releasing peptide (GRP) was isolated from the porcine stomach, and was believed to be the mammalian counterpart of the amphibian peptide bombesin-itself originally isolated from the porcine stomach and subsequently in other vertebrates. A large body of research indicates that GRP is distributed widely in the central nervous system of mammals in addition to the gastrointestinal tract. In mammals, bombesin-like peptides act through a family of at least three GPCRs, namely the GRP-preferring receptor (GRPR), the neuromedin B-preferring receptor (NMBR), and the bombesin receptor subtype-3 (BRS-3), which is considered an orphan receptor. To date, it has been reported that GRP plays significant roles in many physiological processes, including food intake, circadian rhythms, male sexual behavior, sigh control, and fear memory consolidation, through the specific GRPR-mediated mechanisms.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
PublisherElsevier
Pages333-335
Number of pages3
ISBN (Electronic)9780128206492
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • Bombesin
  • Bombesin-like peptide (BLP)
  • Central nervous system and gastrointestinal tract
  • Gastrin-releasing peptide (GRP)
  • Gastrin-releasing peptide receptor (GRPR)

ASJC Scopus subject areas

  • Medicine(all)

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