Gastric mucosal protection and superoxide dismutase

Keiki Ogino, Shinji Oka, Yukinori Okazaki, Tadayoshi Takemoto

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.

Original languageEnglish
Pages (from-to)S129-S132
JournalJournal of Clinical Gastroenterology
Volume10
Publication statusPublished - 1988
Externally publishedYes

Fingerprint

Peroxides
Superoxide Dismutase
Amitrole
Stomach
Ditiocarb
Stomach Ulcer
Catalase
Reactive Oxygen Species

Keywords

  • Aminotriazole
  • Diethyldithiocarbamate
  • Gastric ulcer
  • Superoxide dismutase

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ogino, K., Oka, S., Okazaki, Y., & Takemoto, T. (1988). Gastric mucosal protection and superoxide dismutase. Journal of Clinical Gastroenterology, 10, S129-S132.

Gastric mucosal protection and superoxide dismutase. / Ogino, Keiki; Oka, Shinji; Okazaki, Yukinori; Takemoto, Tadayoshi.

In: Journal of Clinical Gastroenterology, Vol. 10, 1988, p. S129-S132.

Research output: Contribution to journalArticle

Ogino, K, Oka, S, Okazaki, Y & Takemoto, T 1988, 'Gastric mucosal protection and superoxide dismutase', Journal of Clinical Gastroenterology, vol. 10, pp. S129-S132.
Ogino K, Oka S, Okazaki Y, Takemoto T. Gastric mucosal protection and superoxide dismutase. Journal of Clinical Gastroenterology. 1988;10:S129-S132.
Ogino, Keiki ; Oka, Shinji ; Okazaki, Yukinori ; Takemoto, Tadayoshi. / Gastric mucosal protection and superoxide dismutase. In: Journal of Clinical Gastroenterology. 1988 ; Vol. 10. pp. S129-S132.
@article{c62539a974cc49c786e294ba952f10a7,
title = "Gastric mucosal protection and superoxide dismutase",
abstract = "Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.",
keywords = "Aminotriazole, Diethyldithiocarbamate, Gastric ulcer, Superoxide dismutase",
author = "Keiki Ogino and Shinji Oka and Yukinori Okazaki and Tadayoshi Takemoto",
year = "1988",
language = "English",
volume = "10",
pages = "S129--S132",
journal = "Journal of Clinical Gastroenterology",
issn = "0192-0790",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Gastric mucosal protection and superoxide dismutase

AU - Ogino, Keiki

AU - Oka, Shinji

AU - Okazaki, Yukinori

AU - Takemoto, Tadayoshi

PY - 1988

Y1 - 1988

N2 - Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.

AB - Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.

KW - Aminotriazole

KW - Diethyldithiocarbamate

KW - Gastric ulcer

KW - Superoxide dismutase

UR - http://www.scopus.com/inward/record.url?scp=0023682503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023682503&partnerID=8YFLogxK

M3 - Article

C2 - 2846684

AN - SCOPUS:0023682503

VL - 10

SP - S129-S132

JO - Journal of Clinical Gastroenterology

JF - Journal of Clinical Gastroenterology

SN - 0192-0790

ER -