Gastric mucosal protection and superoxide dismutase

Keiki Ogino, Shinji Oka, Yukinori Okazaki, Tadayoshi Takemoto

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Diethyldithiocarbamate (DDC), an inhibitor of Cu, Zn-su-peroxide dismutase (SOD), at a dose of 500 mg/kg or aminotriazole (AT), an inhibitor of catalase, at a dose of 2,000 mg/kg reduced slightly gastric mucosal SOD activity, did not change gastric mucosal blood flow (GMBF), and did not cause gastric ulcers. However, when both DDC and AT were administered together, gastric mucosal SOD activity and GMBF remarkably decreased, and gastric ulcers appeared. Moreover, the administration of SOD attenuated gastric ulcer induced by DDC plus AT. These results suggested that SOD may play an important role in the gastric mucosal defense mechanisms against active oxygen species.

Original languageEnglish
Pages (from-to)S129-S132
JournalJournal of Clinical Gastroenterology
Volume10
DOIs
Publication statusPublished - Dec 1988

Keywords

  • Aminotriazole
  • Diethyldithiocarbamate
  • Gastric ulcer
  • Superoxide dismutase

ASJC Scopus subject areas

  • Gastroenterology

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