Gastric mucosal injury induced by chloral hydrate

Ogino Keiki; Hobara Tatuya; Kobayashi Haruo; Iwamoto Susumu

doi:10.1016/0378-4274(90)90146-D

Gastric mucosal injury induced by chloral hydrate

Ogino Keiki, Hobara Tatuya, Kobayashi Haruo, Iwamoto Susumu

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Gastric mucosal injury by chloral hydrate (CH) was investigated in the rat. Rats were injected with CH intraperitoneally or subcutaneously. After the CH injection, gastric ulcers appeared in the glandular stomach at 6 h and the ulcer index peaked in 12 h. The minimum dosage of CH to produce ulcers was 400 mg/ kg intraperitoneally and 600 mg/kg subcutaneously.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Toxicology Letters
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(90)90146-D
Publication status	Published - Jul 1990

Keywords

Chloral hydrate
Stomach
Ulcer

ASJC Scopus subject areas

Toxicology

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AU - Haruo, Kobayashi

AU - Susumu, Iwamoto

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KW - Chloral hydrate

KW - Stomach

KW - Ulcer

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