Gamma-interferon upregulates transferrin receptors and decreases membrane microviscosity in K562 cells

Hiromi Iwagaki, Masahito Marutaka, Tadashi Yoshino, Liu Cao, Isao Sakuma, Masashi Uomoto, Yoshiaki Takeuchi, Noriaki Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the effect of gamma interferon (γ-IFN) on three cellular parameters: cell membrane fluidity and expression of two antigens that have been associated with cell proliferation, namely transferrin receptor (Tf-R: a cell surface protein) and Ki-67 antigen (Ki-67: a nuclear protein). We observed small, yet significant changes in the first two parameters, but not the third parameter. These were investigated in K562 cells, a human chronic myelocytic leukemia cell line. These results suggest that the microviscosity changes and the surface Tf-R density were closely associated, and that γ- IFN was involved in increasing proliferative activity of the cells by decreasing membrane fluidity and upregulating Tf-R expression.

Original languageEnglish
Pages (from-to)191-200
Number of pages10
JournalResearch Communications in Molecular Pathology and Pharmacology
Volume92
Issue number2
Publication statusPublished - May 1996

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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