Galectins, galactoside-binding mammalian lectins

Clinical application of multi-functional proteins

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Galectins are β-galactoside binding mammalian lectins and they share homologous carbohydrate recognition domains. To date, 11 members of galectin family have been cloned and identified. They have been shown to play roles in diverse biological events, such as embryogenesis, oncogenesis, adhesion and proliferation of the cells, receptor for advanced glycation end products, mRNA splicing, bacterial colonization, apoptosis, and in the modulation of the immune response. The mechanisms by which galectins exert these diverse effects remain largely unknown. However, the elucidation of multi-functional proteins belong to galectin family are going to open new fields in clinical science including diagnosis and therapy of autoimmune disorders, cancers, and vascular complications in diabetes and hypertension.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalActa Medica Okayama
Volume55
Issue number1
Publication statusPublished - Dec 1 2001

Fingerprint

Galectins
Galactosides
Lectins
Proteins
Diabetes Complications
Medical problems
Cell Adhesion
Embryonic Development
Blood Vessels
Carcinogenesis
Adhesion
Carbohydrates
Cell Proliferation
Modulation
Apoptosis
Hypertension
Messenger RNA
Neoplasms

Keywords

  • β-galactoside binding lectins
  • Apoptosis
  • Autoimmune diseases
  • Cell adhesion and proliferation
  • Diabetic vascular complications
  • Galectins
  • Oncogenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Galectins, galactoside-binding mammalian lectins : Clinical application of multi-functional proteins. / Wada, Jun; Makino, Hirofumi.

In: Acta Medica Okayama, Vol. 55, No. 1, 01.12.2001, p. 11-17.

Research output: Contribution to journalReview article

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