Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

Masako Seki, Souichi Oomizu, Ken mei Sakata, Atsuko Sakata, Tomohiro Arikawa, Kota Watanabe, Kanako Ito, Keisuke Takeshita, Toshiro Niki, Naoki Saita, Nozomu Nishi, Akira Yamauchi, Shigeki Katoh, Akihiro Matsukawa, Vijay Kuchroo, Mitsuomi Hirashima

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310 Citations (Scopus)

Abstract

The effects of galectin-9 on a mouse collagen-induced arthritis (CIA) model were assessed to clarify whether galectin-9 suppresses CIA by regulating T cell immune responses. Galectin-9 suppressed CIA in a dose-dependent manner, and such suppression was observed even when treatment was started on 7 days after the booster, indicating its preventive and therapeutic effects. Galectin-9 induced the decreased levels of pro-inflammatory cytokines, IL-17, IL-12, and IFNγ in the joint. Galectin-9 induced the decreased number of CD4+ TIM-3+ T cells in peripheral blood. Galectin-9-deficient mice became susceptible to CIA may be by increased number of CD4+ TIM-3+ T cells and decreased number of Treg cells. We further found that galectin-9 induces differentiation of naive T cells to Treg cells, and it suppresses differentiation to Th17 cells in vitro. The present results suggested that galectin-9 ameliorates CIA by suppressing the generation of Th17, promoting the induction of regulatory T cells.

Original languageEnglish
Pages (from-to)78-88
Number of pages11
JournalClinical Immunology
Volume127
Issue number1
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Collagen-induced arthritis
  • Galectin-9
  • Pro-inflammatory cytokines
  • Regulatory T cells
  • Rodent
  • T cell immunoglobulin- and mucin domain-containing molecule 3
  • Th1
  • Th17

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Seki, M., Oomizu, S., Sakata, K. M., Sakata, A., Arikawa, T., Watanabe, K., Ito, K., Takeshita, K., Niki, T., Saita, N., Nishi, N., Yamauchi, A., Katoh, S., Matsukawa, A., Kuchroo, V., & Hirashima, M. (2008). Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clinical Immunology, 127(1), 78-88. https://doi.org/10.1016/j.clim.2008.01.006