Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages

Tomohiro Arikawa, Kota Watanabe, Masako Seki, Akihiro Matsukawa, Souichi Oomizu, Ken mei Sakata, Atsuko Sakata, Masaki Ueno, Naoki Saita, Toshiro Niki, Akira Yamauchi, Mitsuomi Hirashima

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36 Citations (Scopus)

Abstract

Galectin-9 up-regulated FcγRIIb expression of mouse peritoneal macrophages in vitro but down-regulated FcγRIII expression. Galectin-9-treated macrophages stimulated with immune complexes (IC) produced less TNFα and IL-1β but more IL-10 than PBS-treated macrophages. Macrophage enhancing effects on IC-induced C5a and neutrophil chemotactic activity were also diminished for galectin-9-treated macrophages. In galectin-9-treated mice, the severity of IC-induced arthritis was reduced, as were pro-inflammatory cytokine levels in inflamed joints and serum C5a. FcγRIIb expression of macrophages from galectin-9-treated mice was up-regulated, whereas FcγRIII expression was down-regulated. Macrophages from galectin-9-treated mice produced less TNFα and IL-1β but more IL-10 than PBS-treated mice. Disease severity of galectin-9-transgenic mice was milder than wild-type mice, whereas that of galectin-9-deficient mice was exaggerated. Furthermore, macrophage FcγRIIb expression in galectin-9-deficient mice was down-regulated, while FcγRIII expression was up-regulated. These results suggest that galectin-9 suppresses IC-induced inflammation partly by regulating FcγR expression on macrophages.

Original languageEnglish
Pages (from-to)382-392
Number of pages11
JournalClinical Immunology
Volume133
Issue number3
DOIs
Publication statusPublished - Dec 1 2009

Keywords

  • Arthritis
  • FcγRIII
  • FcγRIIb
  • Galectin-9
  • Immune complex
  • Macrophage

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Arikawa, T., Watanabe, K., Seki, M., Matsukawa, A., Oomizu, S., Sakata, K. M., Sakata, A., Ueno, M., Saita, N., Niki, T., Yamauchi, A., & Hirashima, M. (2009). Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages. Clinical Immunology, 133(3), 382-392. https://doi.org/10.1016/j.clim.2009.09.004