Galanin Inhibits Noradrenaline‐Induced Accumulation of Cyclic AMP in the Rat Cerebral Cortex

Masahiro Nishibori, Ryozo Oishi, Yoshinori Itoh, Kiyomi Saeki

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Abstract: The effect of galanin on poradrenaline (NA)‐induced accumulation of cyclic AMP was investigated in slices of rat cerebral cortex. NA (10−4M) increased cyclic AMP levels during a 20‐min observation period. Galanin (3 × 10−7M) significantly inhibited this response at all time points examined, although it did not change the basal levels of cyclic AMP. Galanin (10−3× 10−6M) inhibited the cyclic AMP response to NA (10−4M) in a dose‐dependent manner, with an IC50 of ∼5.6 × 10−5M and a maximum inhibition of 59%. These results suggest that galanin, devoid of any detectable effects by itself, modulates the cyclic AMP response to NA in the rat cerebral cortex.

Original languageEnglish
Pages (from-to)1953-1955
Number of pages3
JournalJournal of Neurochemistry
Volume51
Issue number6
DOIs
Publication statusPublished - Dec 1988

Keywords

  • Cyclic AMP accumulation
  • Galanin
  • Noradrenaline

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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