GABA-Induced GnRH Release Triggers Chordate Metamorphosis

Akiko Hozumi; Shohei Matsunobu; Kaoru Mita; Nicholas Treen; Takaho Sugihara; Takeo Horie; Tetsushi Sakuma; Takashi Yamamoto; Akira Shiraishi; Mayuko Hamada; Noriyuki Satoh; Keisuke Sakurai; Honoo Satake; Yasunori Sasakura

doi:10.1016/j.cub.2020.02.003

GABA-Induced GnRH Release Triggers Chordate Metamorphosis

Akiko Hozumi, Shohei Matsunobu, Kaoru Mita, Nicholas Treen, Takaho Sugihara, Takeo Horie, Tetsushi Sakuma, Takashi Yamamoto, Akira Shiraishi, Mayuko Hamada, Noriyuki Satoh, Keisuke Sakurai, Honoo Satake, Yasunori Sasakura

Faculty of Science

Research output: Contribution to journal › Article

Abstract

Metamorphosis is a dramatic body change in metazoans that allows the use of different ecological niches. Hozumi et al. show that GABA is a key regulator of metamorphosis in the ascidian Ciona. During this process, GABA, generally thought of as an inhibitory neurotransmitter, positively regulates secretion of the neuropeptide GnRH.

Original language	English
Pages (from-to)	1555-1561.e4
Journal	Current Biology
Volume	30
Issue number	8
DOIs	https://doi.org/10.1016/j.cub.2020.02.003
Publication status	Published - Apr 20 2020

Keywords

ascidian
gamma aminobutyric acid
gonadotropin-releasing hormone
tail regression

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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10.1016/j.cub.2020.02.003

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Cite this

Hozumi, A., Matsunobu, S., Mita, K., Treen, N., Sugihara, T., Horie, T., Sakuma, T., Yamamoto, T., Shiraishi, A., Hamada, M., Satoh, N., Sakurai, K., Satake, H., & Sasakura, Y. (2020). GABA-Induced GnRH Release Triggers Chordate Metamorphosis. Current Biology, 30(8), 1555-1561.e4. https://doi.org/10.1016/j.cub.2020.02.003

GABA-Induced GnRH Release Triggers Chordate Metamorphosis. / Hozumi, Akiko; Matsunobu, Shohei; Mita, Kaoru; Treen, Nicholas; Sugihara, Takaho; Horie, Takeo; Sakuma, Tetsushi; Yamamoto, Takashi; Shiraishi, Akira; Hamada, Mayuko; Satoh, Noriyuki; Sakurai, Keisuke; Satake, Honoo; Sasakura, Yasunori.

In: Current Biology, Vol. 30, No. 8, 20.04.2020, p. 1555-1561.e4.

Research output: Contribution to journal › Article

Hozumi, Akiko ; Matsunobu, Shohei ; Mita, Kaoru ; Treen, Nicholas ; Sugihara, Takaho ; Horie, Takeo ; Sakuma, Tetsushi ; Yamamoto, Takashi ; Shiraishi, Akira ; Hamada, Mayuko ; Satoh, Noriyuki ; Sakurai, Keisuke ; Satake, Honoo ; Sasakura, Yasunori. / GABA-Induced GnRH Release Triggers Chordate Metamorphosis. In: Current Biology. 2020 ; Vol. 30, No. 8. pp. 1555-1561.e4.

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