@article{19229b2d2bc0401e9a9dfa6f04df7677,
title = "GABA-Induced GnRH Release Triggers Chordate Metamorphosis",
abstract = "Metamorphosis is a dramatic body change in metazoans that allows the use of different ecological niches. Hozumi et al. show that GABA is a key regulator of metamorphosis in the ascidian Ciona. During this process, GABA, generally thought of as an inhibitory neurotransmitter, positively regulates secretion of the neuropeptide GnRH.",
keywords = "ascidian, gamma aminobutyric acid, gonadotropin-releasing hormone, tail regression",
author = "Akiko Hozumi and Shohei Matsunobu and Kaoru Mita and Nicholas Treen and Takaho Sugihara and Takeo Horie and Tetsushi Sakuma and Takashi Yamamoto and Akira Shiraishi and Mayuko Hamada and Noriyuki Satoh and Keisuke Sakurai and Honoo Satake and Yasunori Sasakura",
note = "Funding Information: This work was supported by grants from the MEXT and JSPS , Japan (nos. 16H04815 , 15K14520 , and 19H03262 ). We thank Atsuo Nishino, Junko Nishino, Aya Sakamoto, Ryusuke Niwa, and Yoshitaka Oka for their helpful discussion for constructing this manuscript. We are grateful to Shigeki Fujiwara, Manabu Yoshida, Yutaka Satou, Chikako Imaizumi, Reiko Yoshida, Satoe Aratake, all members of the Department of Zoology of Kyoto University, the Misaki Marine Biological Station of the University of Tokyo, and the Maizuru Fishery Research Station of Kyoto University for cultivation and provision of wild-type Ciona adults. Funding Information: This work was supported by grants from the MEXT and JSPS, Japan (nos. 16H04815, 15K14520, and 19H03262). We thank Atsuo Nishino, Junko Nishino, Aya Sakamoto, Ryusuke Niwa, and Yoshitaka Oka for their helpful discussion for constructing this manuscript. We are grateful to Shigeki Fujiwara, Manabu Yoshida, Yutaka Satou, Chikako Imaizumi, Reiko Yoshida, Satoe Aratake, all members of the Department of Zoology of Kyoto University, the Misaki Marine Biological Station of the University of Tokyo, and the Maizuru Fishery Research Station of Kyoto University for cultivation and provision of wild-type Ciona adults. A.H. S.M. K.M. and Y.S. designed the study. A.H. S.M. and K.M. performed most experiments with help from N.T. T.H. and T. Sugihara. A.S. H.S. K.S. Y.S. N.T. T.H. T. Sakuma, and T.Y. assisted with gene knockouts. A.S. M.H. N.S. and H.S. analyzed gene expression profiles. Y.S. wrote the manuscript with the aid of A.H. N.T. S.M. K.M. T.H. M.H. and K.S. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = apr,
day = "20",
doi = "10.1016/j.cub.2020.02.003",
language = "English",
volume = "30",
pages = "1555--1561.e4",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "8",
}