GABA-Induced GnRH Release Triggers Chordate Metamorphosis

Akiko Hozumi, Shohei Matsunobu, Kaoru Mita, Nicholas Treen, Takaho Sugihara, Takeo Horie, Tetsushi Sakuma, Takashi Yamamoto, Akira Shiraishi, Mayuko Hamada, Noriyuki Satoh, Keisuke Sakurai, Honoo Satake, Yasunori Sasakura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Metamorphosis is a dramatic body change in metazoans that allows the use of different ecological niches. Hozumi et al. show that GABA is a key regulator of metamorphosis in the ascidian Ciona. During this process, GABA, generally thought of as an inhibitory neurotransmitter, positively regulates secretion of the neuropeptide GnRH.

Original languageEnglish
Pages (from-to)1555-1561.e4
JournalCurrent Biology
Volume30
Issue number8
DOIs
Publication statusPublished - Apr 20 2020

Keywords

  • ascidian
  • gamma aminobutyric acid
  • gonadotropin-releasing hormone
  • tail regression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Hozumi, A., Matsunobu, S., Mita, K., Treen, N., Sugihara, T., Horie, T., Sakuma, T., Yamamoto, T., Shiraishi, A., Hamada, M., Satoh, N., Sakurai, K., Satake, H., & Sasakura, Y. (2020). GABA-Induced GnRH Release Triggers Chordate Metamorphosis. Current Biology, 30(8), 1555-1561.e4. https://doi.org/10.1016/j.cub.2020.02.003