Further investigations on brain distribution of hydra zine and its γ-aminobutyric acid elevating effect in rats

Kenji Matsuyama, Chikamasa Yamashita, Toshiaki Sendoh, Atsuko Noda, Shigeru Goto, Sadao Iguchi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Perry�s hypothesis that hydrazine (Hz) derived from isoniazid (INH) treatment plays an important role in the elevation of brain y-aminobutyric acid (GABA) levels1) was reexamined by measuring Hz and GABA levels in the brain after the treatment with 50 mg/kg of INH or different doses of Hz. The treatment with 50 mg/kg of INH to rats resulted in the elevation of GABA levels in rat whole brain. The maximum levels of GABA increased about twice at 4 h from 2.06 �0.4umol/g wet wt. in the control group to 3-61 �0.4umol/g wet wt. in INH treated group. In this case, brain levels of Hz ranged from 25.6 to 80.8 ng/g wet wt. within 10 h.

Original languageEnglish
Pages (from-to)932-937
Number of pages6
JournalJournal of Pharmacobio-Dynamics
Volume6
Issue number12
DOIs
Publication statusPublished - Jan 1 1983
Externally publishedYes

Fingerprint

hydrazine
Hydra
Aminobutyrates
gamma-Aminobutyric Acid
Brain
Isoniazid
Control Groups

Keywords

  • brain level
  • GABA
  • GC-MS analysis
  • hydrazine
  • isoniazid

ASJC Scopus subject areas

  • Pharmacology

Cite this

Further investigations on brain distribution of hydra zine and its γ-aminobutyric acid elevating effect in rats. / Matsuyama, Kenji; Yamashita, Chikamasa; Sendoh, Toshiaki; Noda, Atsuko; Goto, Shigeru; Iguchi, Sadao.

In: Journal of Pharmacobio-Dynamics, Vol. 6, No. 12, 01.01.1983, p. 932-937.

Research output: Contribution to journalArticle

Matsuyama, Kenji ; Yamashita, Chikamasa ; Sendoh, Toshiaki ; Noda, Atsuko ; Goto, Shigeru ; Iguchi, Sadao. / Further investigations on brain distribution of hydra zine and its γ-aminobutyric acid elevating effect in rats. In: Journal of Pharmacobio-Dynamics. 1983 ; Vol. 6, No. 12. pp. 932-937.
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