Abstract
Objectives: This study aimed to assess the fate of tricuspid regurgitation (TR) after transcatheter atrial septal defect (ASD) closure. Background: Although TR frequently occurs in patients with ASD, the change in TR during long-term follow-up after ASD closure remains unknown. Methods: A total of 419 adult patients who underwent transcatheter ASD closure were enrolled. TR severity was graded by TR jet area on echocardiography. Results: At baseline, 113 patients had severe/moderate TR and 306 patients had mild TR. Among the 113 patients with severe/moderate TR, the TR jet area significantly decreased during a median follow-up of 30 months after the procedure; this decrease was related to the improvement in right ventricular morphology. The severity of TR decreased to mild in 79 (70%) patients. Persistent TR, defined as severe or moderate TR after the procedure, was independently associated with the prevalence of permanent atrial fibrillation. Regarding clinical outcomes, 7 patients with severe/moderate TR and 2 with mild TR were hospitalized because of heart failure. Patients with severe/moderate TR had the worse event-free survival rate than those with mild TR, but more than 90% of them had no cardiovascular events. New York Heart Association functional class and plasma B-type natriuretic peptide levels improved in patients with severe/moderate TR, similar to those with mild TR. Conclusions: Significant TR decreased during the long-term follow-up period after transcatheter ASD closure. Heart failure symptoms improved in patients with severe/moderate TR. Our findings suggest that transcatheter closure alone can be valuable in patients with ASD complicated with TR.
| Original language | English |
|---|---|
| Journal | JACC: Cardiovascular Interventions |
| DOIs | |
| Publication status | Accepted/In press - 2017 |
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Keywords
- Atrial septal defect
- Outcome
- Transcatheter closure
- Tricuspid regurgitation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Functional Tricuspid Regurgitation After Transcatheter Closure of Atrial Septal Defect in Adult Patients. Long-Term Follow-Up. / Takaya, Yoichi; Akagi, Teiji; Kijima, Yasufumi; Nakagawa, Koji; Itoh, Hiroshi.
In: JACC: Cardiovascular Interventions, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional Tricuspid Regurgitation After Transcatheter Closure of Atrial Septal Defect in Adult Patients. Long-Term Follow-Up
AU - Takaya, Yoichi
AU - Akagi, Teiji
AU - Kijima, Yasufumi
AU - Nakagawa, Koji
AU - Itoh, Hiroshi
PY - 2017
Y1 - 2017
N2 - Objectives: This study aimed to assess the fate of tricuspid regurgitation (TR) after transcatheter atrial septal defect (ASD) closure. Background: Although TR frequently occurs in patients with ASD, the change in TR during long-term follow-up after ASD closure remains unknown. Methods: A total of 419 adult patients who underwent transcatheter ASD closure were enrolled. TR severity was graded by TR jet area on echocardiography. Results: At baseline, 113 patients had severe/moderate TR and 306 patients had mild TR. Among the 113 patients with severe/moderate TR, the TR jet area significantly decreased during a median follow-up of 30 months after the procedure; this decrease was related to the improvement in right ventricular morphology. The severity of TR decreased to mild in 79 (70%) patients. Persistent TR, defined as severe or moderate TR after the procedure, was independently associated with the prevalence of permanent atrial fibrillation. Regarding clinical outcomes, 7 patients with severe/moderate TR and 2 with mild TR were hospitalized because of heart failure. Patients with severe/moderate TR had the worse event-free survival rate than those with mild TR, but more than 90% of them had no cardiovascular events. New York Heart Association functional class and plasma B-type natriuretic peptide levels improved in patients with severe/moderate TR, similar to those with mild TR. Conclusions: Significant TR decreased during the long-term follow-up period after transcatheter ASD closure. Heart failure symptoms improved in patients with severe/moderate TR. Our findings suggest that transcatheter closure alone can be valuable in patients with ASD complicated with TR.
AB - Objectives: This study aimed to assess the fate of tricuspid regurgitation (TR) after transcatheter atrial septal defect (ASD) closure. Background: Although TR frequently occurs in patients with ASD, the change in TR during long-term follow-up after ASD closure remains unknown. Methods: A total of 419 adult patients who underwent transcatheter ASD closure were enrolled. TR severity was graded by TR jet area on echocardiography. Results: At baseline, 113 patients had severe/moderate TR and 306 patients had mild TR. Among the 113 patients with severe/moderate TR, the TR jet area significantly decreased during a median follow-up of 30 months after the procedure; this decrease was related to the improvement in right ventricular morphology. The severity of TR decreased to mild in 79 (70%) patients. Persistent TR, defined as severe or moderate TR after the procedure, was independently associated with the prevalence of permanent atrial fibrillation. Regarding clinical outcomes, 7 patients with severe/moderate TR and 2 with mild TR were hospitalized because of heart failure. Patients with severe/moderate TR had the worse event-free survival rate than those with mild TR, but more than 90% of them had no cardiovascular events. New York Heart Association functional class and plasma B-type natriuretic peptide levels improved in patients with severe/moderate TR, similar to those with mild TR. Conclusions: Significant TR decreased during the long-term follow-up period after transcatheter ASD closure. Heart failure symptoms improved in patients with severe/moderate TR. Our findings suggest that transcatheter closure alone can be valuable in patients with ASD complicated with TR.
KW - Atrial septal defect
KW - Outcome
KW - Transcatheter closure
KW - Tricuspid regurgitation
UR - http://www.scopus.com/inward/record.url?scp=85031794367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031794367&partnerID=8YFLogxK
U2 - 10.1016/j.jcin.2017.06.022
DO - 10.1016/j.jcin.2017.06.022
M3 - Article
C2 - 29055761
AN - SCOPUS:85031794367
JO - JACC: Cardiovascular Interventions
JF - JACC: Cardiovascular Interventions
SN - 1936-8798
ER -