Functional response of tumor vasculature to PaCO2: Determination of total and microvascular blood volume by MRI

Scott D. Packard, Joseph B. Mandeville, Tomotsugu Ichikawa, Keiro Ikeda, Kinya Terada, Stephanie Niloff, E. Antonio Chiocca, Bruce R. Rosen, John J A Marota

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In order to identify differences in functional activity, we compared the reactivity of glioma vasculature and the native cerebral vasculature to both dilate and constrict in response to altered PaCO2. Gliomas were generated by unilateral implantation of U87MGdEGFR human glioma tumor cells into the striatum of adult female athymic rats. Relative changes in total and microvascular cerebral blood volume were determined by steady state contrast agent-enhanced magnetic resonance imaging for transitions from normocarbia to hypercarbia and hypocarbia. Although hypercarbia induced a significant increase in both total and microvascular blood volume in normal brain and glioma, reactivity of glioma vasculature was significantly blunted in comparison to normal striatum; glioma total CBV increased by 0.6±0.1%/mm Hg CO2 whereas normal striatum increased by 1.5±0.2%/mm Hg CO2, (P2. Furthermore, reduced reactivity of tumor vessels to a single physiological perturbation, such as hypercarbia, should not be construed as a generalized reduction of functional activity of the tumor vascular bed.

Original languageEnglish
Pages (from-to)330-338
Number of pages9
JournalNeoplasia (United States)
Volume5
Issue number4
Publication statusPublished - Jul 2003
Externally publishedYes

Fingerprint

Blood Volume
Glioma
Hypercapnia
Neoplasms
Nude Rats
Contrast Media
Blood Vessels
Magnetic Resonance Imaging
Brain

Keywords

  • Cerebral blood volume
  • CO reactivity
  • Glioma
  • MRI
  • Vasculature

ASJC Scopus subject areas

  • Cancer Research

Cite this

Packard, S. D., Mandeville, J. B., Ichikawa, T., Ikeda, K., Terada, K., Niloff, S., ... Marota, J. J. A. (2003). Functional response of tumor vasculature to PaCO2: Determination of total and microvascular blood volume by MRI. Neoplasia (United States), 5(4), 330-338.

Functional response of tumor vasculature to PaCO2 : Determination of total and microvascular blood volume by MRI. / Packard, Scott D.; Mandeville, Joseph B.; Ichikawa, Tomotsugu; Ikeda, Keiro; Terada, Kinya; Niloff, Stephanie; Chiocca, E. Antonio; Rosen, Bruce R.; Marota, John J A.

In: Neoplasia (United States), Vol. 5, No. 4, 07.2003, p. 330-338.

Research output: Contribution to journalArticle

Packard, SD, Mandeville, JB, Ichikawa, T, Ikeda, K, Terada, K, Niloff, S, Chiocca, EA, Rosen, BR & Marota, JJA 2003, 'Functional response of tumor vasculature to PaCO2: Determination of total and microvascular blood volume by MRI', Neoplasia (United States), vol. 5, no. 4, pp. 330-338.
Packard SD, Mandeville JB, Ichikawa T, Ikeda K, Terada K, Niloff S et al. Functional response of tumor vasculature to PaCO2: Determination of total and microvascular blood volume by MRI. Neoplasia (United States). 2003 Jul;5(4):330-338.
Packard, Scott D. ; Mandeville, Joseph B. ; Ichikawa, Tomotsugu ; Ikeda, Keiro ; Terada, Kinya ; Niloff, Stephanie ; Chiocca, E. Antonio ; Rosen, Bruce R. ; Marota, John J A. / Functional response of tumor vasculature to PaCO2 : Determination of total and microvascular blood volume by MRI. In: Neoplasia (United States). 2003 ; Vol. 5, No. 4. pp. 330-338.
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