TY - JOUR
T1 - Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation
AU - Kubota, Satoshi
AU - Nosaka, Tetsuya
AU - Furuta, Rika
AU - Maki, Masatoshi
AU - Hatanaka, Masakazu
PY - 1991/8/15
Y1 - 1991/8/15
N2 - A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1(HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of both proteins and their responsive RNA elements, respectively.
AB - A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1(HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of both proteins and their responsive RNA elements, respectively.
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U2 - 10.1016/0006-291X(91)91024-7
DO - 10.1016/0006-291X(91)91024-7
M3 - Article
C2 - 1872842
AN - SCOPUS:0025936247
SN - 0006-291X
VL - 178
SP - 1226
EP - 1232
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -
