Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation

Satoshi Kubota, Tetsuya Nosaka, Rika Furuta, Masatoshi Maki, Masakazu Hatanaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1(HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of both proteins and their responsive RNA elements, respectively.

Original languageEnglish
Pages (from-to)1226-1232
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume178
Issue number3
DOIs
Publication statusPublished - Aug 15 1991
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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