Functional computed tomography imaging of tumor-induced angiogenesis

Preliminary results of new tracer kinetic modeling using a computer discretization approach

Katsuhiko Kaneoya, Takuya Ueda, Hiroshi Suito, Youhei Nanazawa, Junichi Tamaru, Kouichi Isobe, Yukio Naya, Toyofusa Tobe, Ken Motoori, Seiji Yamamoto, Geoffrey D. Rubin, Manabu Minami, Hisao Ito

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose. The aim of this study was to establish functional computed tomography (CT) imaging as a method for assessing tumor-induced angiogenesis. Materials and methods. Functional CT imaging was mathematically analyzed for 14 renal cell carcinomas by means of two-compartment modeling using a computer-discretization approach. The model incorporated diffusible kinetics of contrast medium including leakage from the capillary to the extravascular compartment and back-flux to the capillary compartment. The correlations between functional CT parameters [relative blood volume (rbv), permeability 1 (Pm1), and permeability 2 (Pm2)] and histopathological markers of angiogenesis [microvessel density (MVD) and vascular endothelial growth factor (VEGF)] were statistically analyzed. Results. The modeling was successfully performed, showing similarity between the mathematically simulated curve and the measured time-density curve. There were significant linear correlations between MVD grade and Pm1 (r = 0.841, P = 0.001) and between VEGF grade and Pm2 (r = 0.804, P = 0.005) by Pearson's correlation coefficient. Conclusion. This method may be a useful tool for the assessment of tumor-induced angiogenesis.

Original languageEnglish
Pages (from-to)213-221
Number of pages9
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume26
Issue number4
DOIs
Publication statusPublished - May 2008

Fingerprint

angiogenesis
tracers
Permeability
permeability
compartments
tumors
tomography
Tomography
kinetics
Microvessels
Vascular Endothelial Growth Factor A
grade
Neoplasms
blood volume
curves
Blood Volume
Renal Cell Carcinoma
correlation coefficients
markers
Contrast Media

Keywords

  • CT perfusion
  • Functional CT imaging
  • Tumor-induced angiogenesis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Functional computed tomography imaging of tumor-induced angiogenesis : Preliminary results of new tracer kinetic modeling using a computer discretization approach. / Kaneoya, Katsuhiko; Ueda, Takuya; Suito, Hiroshi; Nanazawa, Youhei; Tamaru, Junichi; Isobe, Kouichi; Naya, Yukio; Tobe, Toyofusa; Motoori, Ken; Yamamoto, Seiji; Rubin, Geoffrey D.; Minami, Manabu; Ito, Hisao.

In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 26, No. 4, 05.2008, p. 213-221.

Research output: Contribution to journalArticle

Kaneoya, K, Ueda, T, Suito, H, Nanazawa, Y, Tamaru, J, Isobe, K, Naya, Y, Tobe, T, Motoori, K, Yamamoto, S, Rubin, GD, Minami, M & Ito, H 2008, 'Functional computed tomography imaging of tumor-induced angiogenesis: Preliminary results of new tracer kinetic modeling using a computer discretization approach', Radiation Medicine - Medical Imaging and Radiation Oncology, vol. 26, no. 4, pp. 213-221. https://doi.org/10.1007/s11604-007-0217-4
Kaneoya, Katsuhiko ; Ueda, Takuya ; Suito, Hiroshi ; Nanazawa, Youhei ; Tamaru, Junichi ; Isobe, Kouichi ; Naya, Yukio ; Tobe, Toyofusa ; Motoori, Ken ; Yamamoto, Seiji ; Rubin, Geoffrey D. ; Minami, Manabu ; Ito, Hisao. / Functional computed tomography imaging of tumor-induced angiogenesis : Preliminary results of new tracer kinetic modeling using a computer discretization approach. In: Radiation Medicine - Medical Imaging and Radiation Oncology. 2008 ; Vol. 26, No. 4. pp. 213-221.
@article{382b01dcaab44e29874a09190f629b07,
title = "Functional computed tomography imaging of tumor-induced angiogenesis: Preliminary results of new tracer kinetic modeling using a computer discretization approach",
abstract = "Purpose. The aim of this study was to establish functional computed tomography (CT) imaging as a method for assessing tumor-induced angiogenesis. Materials and methods. Functional CT imaging was mathematically analyzed for 14 renal cell carcinomas by means of two-compartment modeling using a computer-discretization approach. The model incorporated diffusible kinetics of contrast medium including leakage from the capillary to the extravascular compartment and back-flux to the capillary compartment. The correlations between functional CT parameters [relative blood volume (rbv), permeability 1 (Pm1), and permeability 2 (Pm2)] and histopathological markers of angiogenesis [microvessel density (MVD) and vascular endothelial growth factor (VEGF)] were statistically analyzed. Results. The modeling was successfully performed, showing similarity between the mathematically simulated curve and the measured time-density curve. There were significant linear correlations between MVD grade and Pm1 (r = 0.841, P = 0.001) and between VEGF grade and Pm2 (r = 0.804, P = 0.005) by Pearson's correlation coefficient. Conclusion. This method may be a useful tool for the assessment of tumor-induced angiogenesis.",
keywords = "CT perfusion, Functional CT imaging, Tumor-induced angiogenesis",
author = "Katsuhiko Kaneoya and Takuya Ueda and Hiroshi Suito and Youhei Nanazawa and Junichi Tamaru and Kouichi Isobe and Yukio Naya and Toyofusa Tobe and Ken Motoori and Seiji Yamamoto and Rubin, {Geoffrey D.} and Manabu Minami and Hisao Ito",
year = "2008",
month = "5",
doi = "10.1007/s11604-007-0217-4",
language = "English",
volume = "26",
pages = "213--221",
journal = "Japanese Journal of Radiology",
issn = "1867-1071",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - Functional computed tomography imaging of tumor-induced angiogenesis

T2 - Preliminary results of new tracer kinetic modeling using a computer discretization approach

AU - Kaneoya, Katsuhiko

AU - Ueda, Takuya

AU - Suito, Hiroshi

AU - Nanazawa, Youhei

AU - Tamaru, Junichi

AU - Isobe, Kouichi

AU - Naya, Yukio

AU - Tobe, Toyofusa

AU - Motoori, Ken

AU - Yamamoto, Seiji

AU - Rubin, Geoffrey D.

AU - Minami, Manabu

AU - Ito, Hisao

PY - 2008/5

Y1 - 2008/5

N2 - Purpose. The aim of this study was to establish functional computed tomography (CT) imaging as a method for assessing tumor-induced angiogenesis. Materials and methods. Functional CT imaging was mathematically analyzed for 14 renal cell carcinomas by means of two-compartment modeling using a computer-discretization approach. The model incorporated diffusible kinetics of contrast medium including leakage from the capillary to the extravascular compartment and back-flux to the capillary compartment. The correlations between functional CT parameters [relative blood volume (rbv), permeability 1 (Pm1), and permeability 2 (Pm2)] and histopathological markers of angiogenesis [microvessel density (MVD) and vascular endothelial growth factor (VEGF)] were statistically analyzed. Results. The modeling was successfully performed, showing similarity between the mathematically simulated curve and the measured time-density curve. There were significant linear correlations between MVD grade and Pm1 (r = 0.841, P = 0.001) and between VEGF grade and Pm2 (r = 0.804, P = 0.005) by Pearson's correlation coefficient. Conclusion. This method may be a useful tool for the assessment of tumor-induced angiogenesis.

AB - Purpose. The aim of this study was to establish functional computed tomography (CT) imaging as a method for assessing tumor-induced angiogenesis. Materials and methods. Functional CT imaging was mathematically analyzed for 14 renal cell carcinomas by means of two-compartment modeling using a computer-discretization approach. The model incorporated diffusible kinetics of contrast medium including leakage from the capillary to the extravascular compartment and back-flux to the capillary compartment. The correlations between functional CT parameters [relative blood volume (rbv), permeability 1 (Pm1), and permeability 2 (Pm2)] and histopathological markers of angiogenesis [microvessel density (MVD) and vascular endothelial growth factor (VEGF)] were statistically analyzed. Results. The modeling was successfully performed, showing similarity between the mathematically simulated curve and the measured time-density curve. There were significant linear correlations between MVD grade and Pm1 (r = 0.841, P = 0.001) and between VEGF grade and Pm2 (r = 0.804, P = 0.005) by Pearson's correlation coefficient. Conclusion. This method may be a useful tool for the assessment of tumor-induced angiogenesis.

KW - CT perfusion

KW - Functional CT imaging

KW - Tumor-induced angiogenesis

UR - http://www.scopus.com/inward/record.url?scp=44449134743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44449134743&partnerID=8YFLogxK

U2 - 10.1007/s11604-007-0217-4

DO - 10.1007/s11604-007-0217-4

M3 - Article

VL - 26

SP - 213

EP - 221

JO - Japanese Journal of Radiology

JF - Japanese Journal of Radiology

SN - 1867-1071

IS - 4

ER -