Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities

Sayaka Watanabe, Fan Yan Wei, Kazuhito Tomizawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Genome-wide association studies (GWASs) have shown that Cdk5 regulatory subunit-associated protein 1-like 1 (Cdkal1) is one of the most reproducible risk genes of type 2 diabetes (T2D). In this review, we overview not only the molecular functions of Cdkal1 but also the phenotypes observed in the knockout (KO) mice. We further discuss the translational approaches to treat T2D with risk variations in cdkal1.

Original languageEnglish
JournalDrug Discovery Today: Disease Models
Volume10
Issue number2
DOIs
Publication statusPublished - Jun 1 2013
Externally publishedYes

Fingerprint

Type 2 Diabetes Mellitus
Genome-Wide Association Study
Protein Subunits
Knockout Mice
Phenotype
Genes

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Functional characterization of Cdkal1, a risk factor of type 2 diabetes, and the translational opportunities. / Watanabe, Sayaka; Wei, Fan Yan; Tomizawa, Kazuhito.

In: Drug Discovery Today: Disease Models, Vol. 10, No. 2, 01.06.2013.

Research output: Contribution to journalArticle

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