Functional alteration of nervous system in renovascular hypertension

Toshihiro Koyama, Yukako Hatanaka, Mitsuhiro Goda, Yoshito Zamami, Narumi Hobara, Hiromu Kawasaki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The role of nitric oxide (NO)-containing nerves in adrenergic neurotransmission in hypertension was studied in mesenteric resistance arteries without endothelium in 2-kidney-1-clip renal hypertensive rats (2K-1C RHR) and shamoperated normotensive rats (Sham-R). Mesenteric vascular beds isolated from 2K-1C RHR and Sham-R were perfused with Krebs solution and changes in perfusion pressure were measured with a pressure transducer. Perfusion of a NO synthase inhibitor, N-ω-nitro-L-arginine methyl ester (L-NAME), markedly augmented vasoconstrictor responses to periarterial nerve stimulation (PNS) without affecting vasoconstriction induced by exogenously injected noradrenaline. L-NAME significantly increased the neurogenic release of NA evoked by PNS in both 2K-1C RHR and Sham-R preparations. The facilitatory effect of L-NAME based on the inhibition of NO production in 2K-1C RHR was less than that in Sham-R. These results suggest that the function of NO-containing nerves, which presynaptically inhibit adrenergic neurotransmission, is decreased in the renovascular hypertensive model rat.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalYakugaku Zasshi
Volume129
Issue number2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Renovascular Hypertension
Nervous System
Kidney
Surgical Instruments
NG-Nitroarginine Methyl Ester
Nitric Oxide
Synaptic Transmission
Adrenergic Agents
Perfusion
Pressure Transducers
Mesenteric Arteries
Vasoconstrictor Agents
Vasoconstriction
Nitric Oxide Synthase
Endothelium
Blood Vessels
Norepinephrine
Hypertension
Pressure

Keywords

  • Adrenergic nerve transmission
  • Nitric oxide
  • Renovascular hypertension

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Koyama, T., Hatanaka, Y., Goda, M., Zamami, Y., Hobara, N., & Kawasaki, H. (2009). Functional alteration of nervous system in renovascular hypertension. Yakugaku Zasshi, 129(2), 185-189. https://doi.org/10.1248/yakushi.129.185

Functional alteration of nervous system in renovascular hypertension. / Koyama, Toshihiro; Hatanaka, Yukako; Goda, Mitsuhiro; Zamami, Yoshito; Hobara, Narumi; Kawasaki, Hiromu.

In: Yakugaku Zasshi, Vol. 129, No. 2, 02.2009, p. 185-189.

Research output: Contribution to journalArticle

Koyama, T, Hatanaka, Y, Goda, M, Zamami, Y, Hobara, N & Kawasaki, H 2009, 'Functional alteration of nervous system in renovascular hypertension', Yakugaku Zasshi, vol. 129, no. 2, pp. 185-189. https://doi.org/10.1248/yakushi.129.185
Koyama, Toshihiro ; Hatanaka, Yukako ; Goda, Mitsuhiro ; Zamami, Yoshito ; Hobara, Narumi ; Kawasaki, Hiromu. / Functional alteration of nervous system in renovascular hypertension. In: Yakugaku Zasshi. 2009 ; Vol. 129, No. 2. pp. 185-189.
@article{c333f1d19cf54772ae06c01c539b7d3b,
title = "Functional alteration of nervous system in renovascular hypertension",
abstract = "The role of nitric oxide (NO)-containing nerves in adrenergic neurotransmission in hypertension was studied in mesenteric resistance arteries without endothelium in 2-kidney-1-clip renal hypertensive rats (2K-1C RHR) and shamoperated normotensive rats (Sham-R). Mesenteric vascular beds isolated from 2K-1C RHR and Sham-R were perfused with Krebs solution and changes in perfusion pressure were measured with a pressure transducer. Perfusion of a NO synthase inhibitor, N-ω-nitro-L-arginine methyl ester (L-NAME), markedly augmented vasoconstrictor responses to periarterial nerve stimulation (PNS) without affecting vasoconstriction induced by exogenously injected noradrenaline. L-NAME significantly increased the neurogenic release of NA evoked by PNS in both 2K-1C RHR and Sham-R preparations. The facilitatory effect of L-NAME based on the inhibition of NO production in 2K-1C RHR was less than that in Sham-R. These results suggest that the function of NO-containing nerves, which presynaptically inhibit adrenergic neurotransmission, is decreased in the renovascular hypertensive model rat.",
keywords = "Adrenergic nerve transmission, Nitric oxide, Renovascular hypertension",
author = "Toshihiro Koyama and Yukako Hatanaka and Mitsuhiro Goda and Yoshito Zamami and Narumi Hobara and Hiromu Kawasaki",
year = "2009",
month = "2",
doi = "10.1248/yakushi.129.185",
language = "English",
volume = "129",
pages = "185--189",
journal = "Yakugaku Zasshi",
issn = "0031-6903",
publisher = "Pharmaceutical Society of Japan",
number = "2",

}

TY - JOUR

T1 - Functional alteration of nervous system in renovascular hypertension

AU - Koyama, Toshihiro

AU - Hatanaka, Yukako

AU - Goda, Mitsuhiro

AU - Zamami, Yoshito

AU - Hobara, Narumi

AU - Kawasaki, Hiromu

PY - 2009/2

Y1 - 2009/2

N2 - The role of nitric oxide (NO)-containing nerves in adrenergic neurotransmission in hypertension was studied in mesenteric resistance arteries without endothelium in 2-kidney-1-clip renal hypertensive rats (2K-1C RHR) and shamoperated normotensive rats (Sham-R). Mesenteric vascular beds isolated from 2K-1C RHR and Sham-R were perfused with Krebs solution and changes in perfusion pressure were measured with a pressure transducer. Perfusion of a NO synthase inhibitor, N-ω-nitro-L-arginine methyl ester (L-NAME), markedly augmented vasoconstrictor responses to periarterial nerve stimulation (PNS) without affecting vasoconstriction induced by exogenously injected noradrenaline. L-NAME significantly increased the neurogenic release of NA evoked by PNS in both 2K-1C RHR and Sham-R preparations. The facilitatory effect of L-NAME based on the inhibition of NO production in 2K-1C RHR was less than that in Sham-R. These results suggest that the function of NO-containing nerves, which presynaptically inhibit adrenergic neurotransmission, is decreased in the renovascular hypertensive model rat.

AB - The role of nitric oxide (NO)-containing nerves in adrenergic neurotransmission in hypertension was studied in mesenteric resistance arteries without endothelium in 2-kidney-1-clip renal hypertensive rats (2K-1C RHR) and shamoperated normotensive rats (Sham-R). Mesenteric vascular beds isolated from 2K-1C RHR and Sham-R were perfused with Krebs solution and changes in perfusion pressure were measured with a pressure transducer. Perfusion of a NO synthase inhibitor, N-ω-nitro-L-arginine methyl ester (L-NAME), markedly augmented vasoconstrictor responses to periarterial nerve stimulation (PNS) without affecting vasoconstriction induced by exogenously injected noradrenaline. L-NAME significantly increased the neurogenic release of NA evoked by PNS in both 2K-1C RHR and Sham-R preparations. The facilitatory effect of L-NAME based on the inhibition of NO production in 2K-1C RHR was less than that in Sham-R. These results suggest that the function of NO-containing nerves, which presynaptically inhibit adrenergic neurotransmission, is decreased in the renovascular hypertensive model rat.

KW - Adrenergic nerve transmission

KW - Nitric oxide

KW - Renovascular hypertension

UR - http://www.scopus.com/inward/record.url?scp=60049092497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60049092497&partnerID=8YFLogxK

U2 - 10.1248/yakushi.129.185

DO - 10.1248/yakushi.129.185

M3 - Article

VL - 129

SP - 185

EP - 189

JO - Yakugaku Zasshi

JF - Yakugaku Zasshi

SN - 0031-6903

IS - 2

ER -