Anti-asparaginyl transfer RNA (tRNA) synthetase (KS) antibodies, detected in <5% patients with antiaminoacyl- tRNA synthetase antibody syndrome, are strongly associated with interstitial pneumonia but not myositis and skin symptoms. A recent report suggested that most patients with interstitial pneumonia and anti-KS antibody (KS-ILD) may present with chronic disease. We herein report a rare case of severe acute respiratory failure in a KS-ILD patient requiring extracorporeal membrane oxygenation (ECMO). ECMO is useful for facilitating not only lung rest until recovery but also the definitive diagnosis and treatment of ILD. KS-ILD can develop acutely with fulminant respiratory failure, as observed in this case.
- anti-ARS antibody syndrome
- anti-asparaginyl tRNA synthetase antibody
- anti-KS antibody
- extracorporeal membrane oxygenation
- interstitial pneumonia
ASJC Scopus subject areas
- Internal Medicine