FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu

Giovanni Lavorgna, Hitoshi Ueda, Joachim Clos, Carl Wu

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

The Drosophila homeobox segmentation gene fushi tarazu (ftz) is expressed in a seven-stripe pattern during early embryogenesis. This characteristic pattern is largely specified by the zebra element located immediately upstream of the ftz transcriptional start site. The FTZ-F1 protein, one of multiple DNA binding factors that interacts with the zebra element, is implicated in the activation of ftz transcription, especially in stripes 1,2,3, and 6. An FTZ-F1 complementary DNA has been cloned by recognition site screening of a Drosophila expression library. The identity of the FTZ-F1 complementary DNA clone was confirmed by immunological cross-reaction with antibodies to FTZ-F1 and by sequence analysis of peptides from purified FTZ-F1 protein. The predicted amino acid sequence of FTZ-F1 revealed that the protein is a member of the nuclear hormone receptor superfamily. This finding raises the possibility that a hormonal ligand affects the expression of a homeobox segmentation gene early in embryonic development.

Original languageEnglish
Pages (from-to)848-851
Number of pages4
JournalScience
Volume252
Issue number5007
DOIs
Publication statusPublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • General

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