FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu

Giovanni Lavorgna, Hitoshi Ueda, Joachim Clos, Carl Wu

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

The Drosophila homeobox segmentation gene fushi tarazu (ftz) is expressed in a seven-stripe pattern during early embryogenesis. This characteristic pattern is largely specified by the zebra element located immediately upstream of the ftz transcriptional start site. The FTZ-F1 protein, one of multiple DNA binding factors that interacts with the zebra element, is implicated in the activation of ftz transcription, especially in stripes 1, 2, 3, and 6. An FTZ-F1 complementary DNA has been cloned by recognition site screening of a Drosophila expression library. The identity of the FTZ-F1 complementary DNA clone was confirmed by immunological cross-reaction with antibodies to FTZ-F1 and by sequence analysis of peptides from purified FTZ-Fl protein. The predicted amino acid sequence of FTZ-F1 revealed that the protein is a member of the nuclear hormone receptor superfamily. This finding raises the possibility that a hormonal ligand affects the expression of a homeobox segmentation gene early in embryonic development.

Original languageEnglish
Pages (from-to)848-851
Number of pages4
JournalScience
Volume252
Issue number5007
Publication statusPublished - May 10 1991
Externally publishedYes

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Steroid Receptors
Equidae
Homeobox Genes
Hormones
Drosophila
Embryonic Development
Complementary DNA
Proteins
Cross Reactions
Protein Sequence Analysis
Cytoplasmic and Nuclear Receptors
Amino Acid Sequence
Clone Cells
Ligands
Antibodies
DNA

ASJC Scopus subject areas

  • General

Cite this

FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu. / Lavorgna, Giovanni; Ueda, Hitoshi; Clos, Joachim; Wu, Carl.

In: Science, Vol. 252, No. 5007, 10.05.1991, p. 848-851.

Research output: Contribution to journalArticle

Lavorgna, G, Ueda, H, Clos, J & Wu, C 1991, 'FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu', Science, vol. 252, no. 5007, pp. 848-851.
Lavorgna, Giovanni ; Ueda, Hitoshi ; Clos, Joachim ; Wu, Carl. / FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu. In: Science. 1991 ; Vol. 252, No. 5007. pp. 848-851.
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