FtsH proteases in chloroplasts and cyanobacteria

Zach Adam, Adi Zaltsman, Galit Sinvany-Villalobo, Wataru Sakamoto

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

FtsH is a membrane-bound ATP-dependent metalloprotease complex found in prokaryotes and organelles of eukaryotic cells. It consists of one or two trans-membrane helices at its amino-terminus, a highly conserved ATPase domain, which relates it to the AAA protein family, and a zinc-binding domain towards its carboxy-terminus that serves as the proteolytic site. Most bacteria contain a single FtsH gene, but the cyanobacterium Synechocystis has four. The Arabidopsis thaliana genome contains 12 genes encoding FtsH proteins, nine of them can be targeted to chloroplasts, whereas the other three are mitochondrial. Chloroplast FtsH protease is located in the thylakoid membrane, where it forms complexes, most likely hexamers, whose ATPase and proteolytic domains are exposed to the stroma. It is involved in the degradation of the D1 protein of photosystem II reaction centre during its repair from photoinhibition, as well as in the degradation of unassembled proteins in the thylakoid and the stroma. In Arabidopsis, FtsH2 is the most abundant isomer, followed by FtsH5, 8 and 1. This hierarchy is well reflected in the severity of the variegated phenotype of mutants in these genes.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalPhysiologia Plantarum
Volume123
Issue number4
DOIs
Publication statusPublished - Apr 2005

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Cyanobacteria
Chloroplasts
Thylakoids
Peptide Hydrolases
proteinases
chloroplasts
Arabidopsis
thylakoids
Proteolysis
adenosinetriphosphatase
Adenosine Triphosphatases
Genes
Synechocystis
D1 protein
Photosystem II Protein Complex
Membranes
genes
Metalloproteases
metalloproteinases
Eukaryotic Cells

ASJC Scopus subject areas

  • Plant Science

Cite this

FtsH proteases in chloroplasts and cyanobacteria. / Adam, Zach; Zaltsman, Adi; Sinvany-Villalobo, Galit; Sakamoto, Wataru.

In: Physiologia Plantarum, Vol. 123, No. 4, 04.2005, p. 386-390.

Research output: Contribution to journalArticle

Adam, Zach ; Zaltsman, Adi ; Sinvany-Villalobo, Galit ; Sakamoto, Wataru. / FtsH proteases in chloroplasts and cyanobacteria. In: Physiologia Plantarum. 2005 ; Vol. 123, No. 4. pp. 386-390.
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