Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline

Nobutoshi Morimoto, Tomoko Kurata, Kota Sato, Yoshio Ikeda, Shuhei Sato, Koji Abe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. Methods: 35 ALS patients [23 patients presenting with limb-type ALS (ALS-limb) and 12 patients presenting with primary bulbar palsy (PBP)-type ALS (ALS-PBP)] and 5 Spinal and Bulbar Muscular Atrophy (SBMA) patients have participated. To assess cognitive function mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), and frontal assessment battery (FAB) were performed. Additionally the time to complete card flipping with a computerized touch panel-type screening test was also examined. To investigate regional cerebral blood flow (rCBF), single-photon emission computed tomography (SPECT) using a 99mTc labeled ethyl cysteinate dimer (99mTc-ECD) were performed. Statistical image analysis was performed using the easy Z-score imaging system (eZIS). Results: HDS-R and FAB scores were significantly lower in the ALS-PBP group than in age- and gender-matched control subjects or ALS-limb groups (p <0.01). The time to complete card flipping was significantly longer in the ALS-PBP group than in the control and ALS-limb groups (p <0.01). Although MMSE, HDS-R and FAB scores and the time to complete card flipping had no correlation with ALS functional rating scale-revised (ALSFRS-R) or Norris-limb scale scores, FAB score (r = 0.63, p <0.01) and the time to complete card flipping (r = - 0.66, p <0.01) were strongly correlated with Norris-bulbar score. The eZIS showed that rCBF of the frontal lobe was more severely declined in ALS-PBP patients than in ALS-limb patients (p <0.05). Conclusion: These results suggest a selective decline of frontal cerebral functions in the ALS-PBP group in relation to their bulbar symptoms and rCBF decline.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalJournal of the Neurological Sciences
Volume319
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2012

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Cerebrovascular Circulation
Progressive Bulbar Palsy
Regional Blood Flow
Amyotrophic Lateral Sclerosis
Extremities
Dementia
Atrophic Muscular Disorders

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Easy Z-score imaging system (eZIS)
  • Frontal assessment battery (FAB)
  • Regional cerebral blood ?ow (rCBF)
  • Spinal and Bulbar Muscular Atrophy (SBMA)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline. / Morimoto, Nobutoshi; Kurata, Tomoko; Sato, Kota; Ikeda, Yoshio; Sato, Shuhei; Abe, Koji.

In: Journal of the Neurological Sciences, Vol. 319, No. 1-2, 15.08.2012, p. 96-101.

Research output: Contribution to journalArticle

Morimoto, Nobutoshi ; Kurata, Tomoko ; Sato, Kota ; Ikeda, Yoshio ; Sato, Shuhei ; Abe, Koji. / Frontal dysfunctions of ALS-PBP patients in relation to their bulbar symptoms and rCBF decline. In: Journal of the Neurological Sciences. 2012 ; Vol. 319, No. 1-2. pp. 96-101.
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abstract = "Background: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50{\%} ALS patients may also have cognitive dysfunction which has not been fully examined. Methods: 35 ALS patients [23 patients presenting with limb-type ALS (ALS-limb) and 12 patients presenting with primary bulbar palsy (PBP)-type ALS (ALS-PBP)] and 5 Spinal and Bulbar Muscular Atrophy (SBMA) patients have participated. To assess cognitive function mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), and frontal assessment battery (FAB) were performed. Additionally the time to complete card flipping with a computerized touch panel-type screening test was also examined. To investigate regional cerebral blood flow (rCBF), single-photon emission computed tomography (SPECT) using a 99mTc labeled ethyl cysteinate dimer (99mTc-ECD) were performed. Statistical image analysis was performed using the easy Z-score imaging system (eZIS). Results: HDS-R and FAB scores were significantly lower in the ALS-PBP group than in age- and gender-matched control subjects or ALS-limb groups (p <0.01). The time to complete card flipping was significantly longer in the ALS-PBP group than in the control and ALS-limb groups (p <0.01). Although MMSE, HDS-R and FAB scores and the time to complete card flipping had no correlation with ALS functional rating scale-revised (ALSFRS-R) or Norris-limb scale scores, FAB score (r = 0.63, p <0.01) and the time to complete card flipping (r = - 0.66, p <0.01) were strongly correlated with Norris-bulbar score. The eZIS showed that rCBF of the frontal lobe was more severely declined in ALS-PBP patients than in ALS-limb patients (p <0.05). Conclusion: These results suggest a selective decline of frontal cerebral functions in the ALS-PBP group in relation to their bulbar symptoms and rCBF decline.",
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AU - Kurata, Tomoko

AU - Sato, Kota

AU - Ikeda, Yoshio

AU - Sato, Shuhei

AU - Abe, Koji

PY - 2012/8/15

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N2 - Background: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. Methods: 35 ALS patients [23 patients presenting with limb-type ALS (ALS-limb) and 12 patients presenting with primary bulbar palsy (PBP)-type ALS (ALS-PBP)] and 5 Spinal and Bulbar Muscular Atrophy (SBMA) patients have participated. To assess cognitive function mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), and frontal assessment battery (FAB) were performed. Additionally the time to complete card flipping with a computerized touch panel-type screening test was also examined. To investigate regional cerebral blood flow (rCBF), single-photon emission computed tomography (SPECT) using a 99mTc labeled ethyl cysteinate dimer (99mTc-ECD) were performed. Statistical image analysis was performed using the easy Z-score imaging system (eZIS). Results: HDS-R and FAB scores were significantly lower in the ALS-PBP group than in age- and gender-matched control subjects or ALS-limb groups (p <0.01). The time to complete card flipping was significantly longer in the ALS-PBP group than in the control and ALS-limb groups (p <0.01). Although MMSE, HDS-R and FAB scores and the time to complete card flipping had no correlation with ALS functional rating scale-revised (ALSFRS-R) or Norris-limb scale scores, FAB score (r = 0.63, p <0.01) and the time to complete card flipping (r = - 0.66, p <0.01) were strongly correlated with Norris-bulbar score. The eZIS showed that rCBF of the frontal lobe was more severely declined in ALS-PBP patients than in ALS-limb patients (p <0.05). Conclusion: These results suggest a selective decline of frontal cerebral functions in the ALS-PBP group in relation to their bulbar symptoms and rCBF decline.

AB - Background: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by progressive degeneration of spinal and bulbar motor neurons. However up to 50% ALS patients may also have cognitive dysfunction which has not been fully examined. Methods: 35 ALS patients [23 patients presenting with limb-type ALS (ALS-limb) and 12 patients presenting with primary bulbar palsy (PBP)-type ALS (ALS-PBP)] and 5 Spinal and Bulbar Muscular Atrophy (SBMA) patients have participated. To assess cognitive function mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), and frontal assessment battery (FAB) were performed. Additionally the time to complete card flipping with a computerized touch panel-type screening test was also examined. To investigate regional cerebral blood flow (rCBF), single-photon emission computed tomography (SPECT) using a 99mTc labeled ethyl cysteinate dimer (99mTc-ECD) were performed. Statistical image analysis was performed using the easy Z-score imaging system (eZIS). Results: HDS-R and FAB scores were significantly lower in the ALS-PBP group than in age- and gender-matched control subjects or ALS-limb groups (p <0.01). The time to complete card flipping was significantly longer in the ALS-PBP group than in the control and ALS-limb groups (p <0.01). Although MMSE, HDS-R and FAB scores and the time to complete card flipping had no correlation with ALS functional rating scale-revised (ALSFRS-R) or Norris-limb scale scores, FAB score (r = 0.63, p <0.01) and the time to complete card flipping (r = - 0.66, p <0.01) were strongly correlated with Norris-bulbar score. The eZIS showed that rCBF of the frontal lobe was more severely declined in ALS-PBP patients than in ALS-limb patients (p <0.05). Conclusion: These results suggest a selective decline of frontal cerebral functions in the ALS-PBP group in relation to their bulbar symptoms and rCBF decline.

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